一般并不认为需要一级预防措施。 然而,外科包皮环切术可预防男性出现这些病情,包皮的存在是阴茎头包皮炎的诱发条件。[37]Morris BJ, Krieger JN. Penile inflammatory skin disorders and the preventive role of circumcision. Int J Prev Med. 2017;8:32.http://www.ncbi.nlm.nih.gov/pubmed/28567234?tool=bestpractice.com[38]Mallon E, Hawkins D, Dinneen M, et al. Circumcision and genital dermatoses. Arch Dermatol. 2000;136:350-354.http://jamanetwork.com/journals/jamadermatology/fullarticle/190052http://www.ncbi.nlm.nih.gov/pubmed/10724196?tool=bestpractice.com[39]Morris BJ. Why circumcision is a biomedical imperative for the 21st century. Bioessays. 2007;29:1147-1158.http://www.ncbi.nlm.nih.gov/pubmed/17935209?tool=bestpractice.com肥胖是硬化性苔藓的一个危险因素。[40]Doiron PR, Bunker CB. Obesity-related male genital lichen sclerosus. J Eur Acad Dermatol Venereol. 2017;31(5):876-879.https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.14035http://www.ncbi.nlm.nih.gov/pubmed/27891728?tool=bestpractice.com
由于人乳头状瘤病毒 (HPV) 感染是包皮龟头炎的强危险因素,故可考虑进行疫苗接种。现在英国政府政策规定对青春期前男孩进行常规接种。[41]Kmietowicz Z. Boys in England to get HPV vaccine from next year. BMJ 2018;362:k3237http://www.ncbi.nlm.nih.gov/pubmed/30042188?tool=bestpractice.com 在美国,推荐对年龄在 11 至 12 岁的男孩进行疫苗接种。[42]Centers for Disease Control and Prevention. HPV vaccines: vaccinating your preteen or teen. 2018. https://www.cdc.gov/https://www.cdc.gov/hpv/parents/vaccine.html