大多数情况下针对潜在疾病,例如肥胖、高胰岛素血症和恶性肿瘤的治疗都是有效的,皮损会逐渐消退。复发的皮肤病变往往预示着潜在疾病的复发。[2]Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol. 1994 Jul;31(1):1-19.http://www.ncbi.nlm.nih.gov/pubmed/8021347?tool=bestpractice.com[9]Moore RL, Devere TS. Epidermal manifestations of internal malignancy. Dermatol Clin. 2008 Jan;26(1):17-29.http://www.ncbi.nlm.nih.gov/pubmed/18023768?tool=bestpractice.com在没有相关疾病或遗传性 AN 的患者中,局部外用或口服药物治疗通常有效,在大多数情况下不会复发。[2]Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol. 1994 Jul;31(1):1-19.http://www.ncbi.nlm.nih.gov/pubmed/8021347?tool=bestpractice.com[20]Houpt KR, Cruz PD. Acanthosis nigricans. In: Freedberg IM, Eisen AZ, Wolff K, et al, eds, Fitzpatrick's dermatology in general medicine, 6th ed. New York, NY; McGraw Hill: 2003: 1796-1801.[24]Hermanns-Le T, Scheen A, Pierard GE. Acanthosis nigricans associated with insulin resistance: pathophysiology and management. Am J Clin Dermatol. 2004;5(3):199-203.http://www.ncbi.nlm.nih.gov/pubmed/15186199?tool=bestpractice.com[38]Blobstein SH. Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. Cutis. 2003 Jan;71(1):33-4.http://www.ncbi.nlm.nih.gov/pubmed/12553628?tool=bestpractice.com[39]Omar HA, Logsdon S, Richards J. Clinical profiles, occurrence, and management of adolescent patients with HAIR-AN syndrome. ScientificWorldJournal. 2004 Jul 8;4:507-11.http://www.ncbi.nlm.nih.gov/pubmed/15258677?tool=bestpractice.com对于采用激光或手术治疗的患者,尽管报告的病例没有复发,由于研究的病例数太少,因此难以准确预测长期复发率。[36]Rosenbach A, Ram R. Treatment of Acanthosis nigricans of the axillae using a long-pulsed (5-msec) alexandrite laser. Dermatol Surg. 2004 Aug;30(8):1158-60.http://www.ncbi.nlm.nih.gov/pubmed/15274711?tool=bestpractice.com[35]Bredlich RO, Krahn G, Kunzi-Rapp K, et al. Continuous-wave carbon dioxide laser therapy in pseudoacanthosis nigricans. Br J Dermatol. 1998 Nov;139(5):937-8.http://www.ncbi.nlm.nih.gov/pubmed/9892981?tool=bestpractice.com[37]Wedge CC, Rootman DS, Hunter W, et al. Malignant acanthosis nigricans. A case report. Ophthalmology. 1993 Oct;100(10):1590-2.http://www.ncbi.nlm.nih.gov/pubmed/8414421?tool=bestpractice.com