溶血性尿毒综合征

神经系统并发症，例如脑病、癫痫发作、卒中和昏迷，见于 25% 的HUS患者。[4]Banatvala N, Griffin PM, Greene KD, et al. The United States national prospective hemolytic uremic syndrome study: microbiologic, serologic, clinical and epidemiologic findings. J Infect Dis. 2001;183:1063-1070.http://www.ncbi.nlm.nih.gov/pubmed/11237831?tool=bestpractice.com[44]Cimolai N, Morrison BJ, Carter JE. Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome. Pediatrics. 1992;90:616-621.http://www.ncbi.nlm.nih.gov/pubmed/1408519?tool=bestpractice.com[65]Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Kidney Int. 2001;60:831-846.http://www.ncbi.nlm.nih.gov/pubmed/11532079?tool=bestpractice.com

心肌功能障碍有时导致充血性心力衰竭和心包积液。[66]Brandt JR, Fouser LS, Watkins LS, et al. Escherichia coli O157:H7-associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers. J Pediatr. 1994;125:519-526.http://www.ncbi.nlm.nih.gov/pubmed/7931869?tool=bestpractice.com

也可见肠道并发症，例如穿孔或肠坏死和胰腺炎。[10]Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet. 2005;365:1073-1086.http://www.ncbi.nlm.nih.gov/pubmed/15781103?tool=bestpractice.com

在感染后期，患者可能患胆道结石病和结肠狭窄。[67]Tapper D, Tarr P, Avner E, et al. Lessons learned in the management of hemolytic uremic syndrome in children. J Pediatr Surg. 1995;30:158-163.http://www.ncbi.nlm.nih.gov/pubmed/7738732?tool=bestpractice.com[68]Brandt JR, Joseph MW, Fouser LS, et al. Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome. Pediatr Nephrol. 1998;12:222-225.http://www.ncbi.nlm.nih.gov/pubmed/9630042?tool=bestpractice.com