BMJ Best Practice
最后审核时间： 七月 2019
最近更新时间： 六月 2019

小结

定义

病史和查体

关键诊断因素

  • 年龄 <15 岁
  • 骨痛和/或肿胀
  • 皮疹
  • 多尿和烦渴
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其他诊断因素

  • 咳嗽和呼吸困难
  • 胸痛
  • 眼眶异常
  • 黄疸
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危险因素

  • 吸烟
  • 甲状腺病家族史
  • 围产期感染
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诊断性检查

首要检查

  • 全血细胞计数 (FBC）
  • 肝功能检查 (LFT)
  • 血清白蛋白
  • 凝血功能检查
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需要考虑的检查

  • 尿渗透压
  • 垂体激素完整评估
  • 肺功能检查 (PFT)
  • 听力测定
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新兴检查

  • 氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET)
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治疗流程

急性

单系统疾病：累及骨骼

单系统疾病：累及皮肤

单系统疾病：累及淋巴结

单系统疾病：累及肺脏

单系统疾病：累及 CNS

多系统疾病

疾病持续状态

复发/难治性疾病

贡献者

作者 查看所有

Professor of Pediatrics

University of Arkansas for Medical Sciences

Arkansas Children’s Hospital

Little Rock

AR

利益冲突披露
KS declares that he serves on the Board of the Histiocytosis Association (a non-profit organisation). He has provided advice for a legal firm reviewing a case of LCH. He receives honoraria for membership of advisory boards to Pfizer and Behring.

Professor Kimo Stine would like to gratefully acknowledge Dr Oussama Abla, a previous contributor to this topic.

利益冲突披露
OA declares that he has no competing interests.

同行评议专家 查看所有

Director of Pediatric Immunology, Hematology, Oncology, Bone Marrow Transplantation, and Autoimmune Diseases

Leiden University Medical Center

Leiden

The Netherlands

利益冲突披露
RME has previously worked with Dr Abla on a review of LCH. RME is an author of several references cited in this topic.

Assistant Professor of Pediatrics

Keck School of Medicine

University of Southern California

Children's Hospital Los Angeles

Los Angeles

CA

利益冲突披露
RJ declares that she has no competing interests.

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