CRPS 患者的人口统计研究少见。CRPS 可分为急性和慢性两种形式,第一年的预后良好,其后的预后较差。[100]de Mos M, Huygen FJ, van der Hoeven-Borgman M, et al. Outcome of the complex regional pain syndrome. Clin J Pain. 2009;25:590-597.http://www.ncbi.nlm.nih.gov/pubmed/19692800?tool=bestpractice.com[101]Schwartzman RJ, Erwin KL, Alexander GM. The natural history of complex regional pain syndrome. Clin J Pain. 2009;25:273-280.http://www.ncbi.nlm.nih.gov/pubmed/19590474?tool=bestpractice.com在迄今最全面的研究中,74% 的 I 型 CRPS 患者得到解决,大多数在第一年内,包括未接受特定干预的许多患者,这表明自发缓解可能较之之前所认为的更常见。[10]Sandroni P, Benrud-Larson LM, McClelland RL, et al. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain. 2003;103:199-207.http://www.ncbi.nlm.nih.gov/pubmed/12749974?tool=bestpractice.com预后与年龄、性别或患处无关,但最佳治愈率与今后骨折的发生率有关 (91%)。[10]Sandroni P, Benrud-Larson LM, McClelland RL, et al. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain. 2003;103:199-207.http://www.ncbi.nlm.nih.gov/pubmed/12749974?tool=bestpractice.com一项 2013 年的综述表明,在更长久的 CRPS-I 中,有关预后的证据太少以至无法得出高质量的结论。[102]Wertli M, Bachmann LM, Weiner SS, et al. Prognostic factors in complex regional pain syndrome 1: a systematic review. J Rehabil Med. 2013;45:225-231.http://www.medicaljournals.se/jrm/content/?doi=10.2340/16501977-1103&html=1http://www.ncbi.nlm.nih.gov/pubmed/23389624?tool=bestpractice.com随后 CRPS 治疗综述表明,其疗法必须是多方面的,但其预后不一定如通常认为的那么差。[103]Gierthmühlen J, Binder A, Baron R. Mechanism-based treatment in complex regional pain syndromes. Nat Rev Neurol. 2014;10:518-528.http://www.ncbi.nlm.nih.gov/pubmed/25134708?tool=bestpractice.com[104]Birklein F, O’Neill D, Schlereth T. Complex regional pain syndrome: an optimistic perspective. Neurology. 2015;84:89-96.http://www.ncbi.nlm.nih.gov/pubmed/25471395?tool=bestpractice.com
无有关 II 型 CRPS 患者的结果研究,但根据临床观察,其也不会采用。