LSC 是一种常见病，但确切的发病率和患病率数据尚不确定。[2]Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8-19.http://www.ncbi.nlm.nih.gov/pubmed/14756886?tool=bestpractice.com据估计，西欧和美国人群中大约有 0.5% 罹患肛门与生殖器 LSC。[2]Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8-19.http://www.ncbi.nlm.nih.gov/pubmed/14756886?tool=bestpractice.com尽管 LSC 的发病率高峰出现在 35 至 50 岁，且在女性中更常见（女性和男性的比例为 2：1），[1]Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008;21:42-46.http://www3.interscience.wiley.com/cgi-bin/fulltext/119418692/HTMLSTARThttp://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com[7]The Primary Care Dermatology Society. Lichen simplex (syn. circumscribed neurodermatitis). October 2016. http://www.pcds.org.uk/ (last accessed 25 October 2016).http://www.pcds.org.uk/clinical-guidance/lichen-simplex-chronicus此疾病可见于任何性别和年龄，包括童年期，此时在男孩中更为常见。[2]Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8-19.http://www.ncbi.nlm.nih.gov/pubmed/14756886?tool=bestpractice.com
