顾名思义,LSC 通常为慢性和复发性疾病,若不及时治疗,可能会无限期存在。[2]Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8-19.http://www.ncbi.nlm.nih.gov/pubmed/14756886?tool=bestpractice.com与其他慢性瘙痒性皮肤疾病(例如结节性痒疹)相似,LSC 的治疗可能相当困难,并且对长期预后仍然需要谨慎。[59]Vaidya DC, Schwartz RA. Prurigo nodularis: a benign dermatosis derived from a persistent pruritus. Acta Dermatovenerol Croat. 2008;16:38-44.http://www.ncbi.nlm.nih.gov/pubmed/18358109?tool=bestpractice.com即使在病损清除后,疾病仍可能在心理应激期复发,或在特应性皮炎中出现继发性 LSC 的情况下,于皮炎复发期复发。[1]Lotti T, Buggaiani G, Prignano F. Prurigo nodularis and lichen simplex chronicus. Dermatol Ther. 2008;21:42-46.http://www3.interscience.wiley.com/cgi-bin/fulltext/119418692/HTMLSTARThttp://www.ncbi.nlm.nih.gov/pubmed/18318884?tool=bestpractice.com一些患者可能需要为期数月或数年的间歇性治疗。[2]Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8-19.http://www.ncbi.nlm.nih.gov/pubmed/14756886?tool=bestpractice.com