BMJ Best Practice
最后审核时间: 六月 2019
最近更新时间: 三月 2019

小结

定义

病史和查体

关键诊断因素

  • 免疫球蛋白 (IgA) 缺乏症
  • 腹泻
  • 腹胀
  • 腹痛/腹部不适

其他诊断因素

  • 家族史
  • 骨质减少/骨质疏松症
  • 疲劳
  • 体重减轻

危险因素

  • 乳糜泻家族史
  • 免疫球蛋白 A 缺乏症
  • 1 型糖尿病
  • 自身免疫性甲状腺病

诊断性检查

首要检查

  • 全血细胞计数和血涂片
  • 抗组织转谷氨酰胺酶 IgA 抗体 (IgA-tTG)
  • 肌内膜抗体 (EMA)
  • 皮肤活检
全部具体信息

需要考虑的检查

  • 人类白细胞抗原 (HLA) 分型
  • 麸质激发试验
全部具体信息

新兴检查

  • 唾液乳糜泻基因检测
全部具体信息

治疗流程

疾病持续状态

贡献者

Clinical Research Fellow in Celiac Disease

Harvard Medical School

Beth Israel Deaconess Medical Center

Boston

MA

利益冲突披露
AT declares that she has no competing interests.
Ciaran P. Kelly MD

Professor of Medicine

Harvard Medical School

Beth Israel Deaconess Medical Center

Boston

MA

利益冲突披露
CPK declares that he has no competing interests.

Dr Amelie Therrien and Professor Ciaran P. Kelly would like to gratefully acknowledge Dr Daniel A. Leffler, a previous contributor to this topic. DAL declares that he has no competing interests.

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Senior Clinical Lecturer and Honorary Consultant Gastroenterologist

Department of Infection, Immunity & Cardiovascular Disease

Sheffield Medical School

Sheffield

UK

利益冲突披露
MK declares that he has no competing interests.

Professor of Medicine

Rosalind Franklin Medical School

Chicago

IL

利益冲突披露
EE declares that he has no competing interests.

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