BMJ Best Practice
最后审核时间: 十月 2018
最近更新时间: 一月 2018

小结

定义

病史和查体

关键诊断因素

  • 新生儿黄疸
  • 无胆汁便

其他诊断因素

  • 小便色深
  • 肝肿大
  • 腹水
  • 瘀伤

危险因素

  • 遗传易感性
  • 病毒感染
  • 环境暴露或行为暴露
  • 母源性糖尿病 (DM)

诊断性检查

首要检查

  • 血清总胆红素和结合胆红素
  • 新生儿筛查(包括对诊断半乳糖血症、甲状腺功能障碍、囊性纤维化及一系列代谢性疾病的检测)
  • 凝血酶原时间 (PT),国际标准化比值 (INR)
  • FBC 和白细胞分类计数
全部具体信息

需要考虑的检查

  • 肝胆闪烁显像(锝 Tc99m- 二异丙基 - 乙酰苯胺 - 亚氨基亚乙酸扫描)
  • 肝脏活检
  • 胆管造影
  • ERCP
全部具体信息

治疗流程

贡献者

Coordinator

Biliary Atresia Research Program

The Children's Hospital of Philadelphia

Philadelphia

PA

利益冲突披露
JE declares that she has no competing interests.

Professor of Pediatrics

Department of Pediatrics

The Children's Hospital of Philadelphia

Philadelphia

PA

利益冲突披露
JAF declares that he has no competing interests.

Associate Professor of Pediatrics

Department of Pediatrics

The Children's Hospital of Philadelphia

Philadelphia

PA

利益冲突披露
KL declares that she has no competing interests.

Dr Jessi Erlichman, Dr Jonathan A. Flick, and Dr Kathleen Loomes would like to gratefully acknowledge Dr Barbara A. Haber, a previous contributor to this monograph. This monograph was first commissioned and written in 2008 when Dr Haber was Professor of Pediatrics at The Children's Hospital of Philadelphia. Dr Haber moved to a position at Merck Sharp & Dohme in 2012.

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Director

Pediatric Hepatology Center

Visiting Professor of Pediatrics

University of Pittsburgh

Pediatric Hepatology Center

Pittsburgh

PA

利益冲突披露
BLS has received research funding from, and been a consultant to, several pharmaceutical companies that make antibiotic agents that might be used for treating bacterial prostatitis.

Former Professor of Paediatric Surgery

University of Otago

Dunedin

New Zealand

利益冲突披露
MDS declares that he has no competing interests.

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