症状控制和神经系统功能恢复:中等质量证据显示,针对短期治疗(1-6 个月),IVIG 相较安慰剂可恢复神经系统功能、增加肌肉强度、改善残疾评分和神经传导检查。[111]Hughes RA, Donofrio P, Bril V, et al. Intravenous immune globulin (10% caprylate chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial. Lancet Neurol. 2008;7:136-144.http://www.ncbi.nlm.nih.gov/pubmed/18178525?tool=bestpractice.com[112]Eftimov F, Winer JB, Vermeulen M, et al. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy. Cochrane Database Syst Rev. 2013;(12):CD001797.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001797.pub3/abstracthttp://www.ncbi.nlm.nih.gov/pubmed/24379104?tool=bestpractice.com[113]Vermeulen M, van Doorn PA, Brand A, et al. Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy: a double blind, placebo controlled study. J Neurol Neurosurg Psychiatry. 1993;56:36-39.http://www.ncbi.nlm.nih.gov/pubmed/8429321?tool=bestpractice.com[114]Thompson N, Choudhary P, Hughes RA, et al. A novel trial design to study the effect of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol. 1996;243:280-285.http://www.ncbi.nlm.nih.gov/pubmed/8936360?tool=bestpractice.com[115]Hahn AF, Bolton CF, Zochodne D, et al. Intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a double-blind, placebo-controlled, cross-over study. Brain. 1996;119:1067-1077.http://brain.oxfordjournals.org/content/119/4/1067.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/8813271?tool=bestpractice.com[116]Mendell JR, Barohn RJ, Freimer ML, et al. Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 2001;56:445-449.http://www.ncbi.nlm.nih.gov/pubmed/11222785?tool=bestpractice.com[117]van Schaik IN, Winer JB, de Haan R, et al. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review. Lancet Neurol. 2002;1:491-498.http://www.ncbi.nlm.nih.gov/pubmed/12849334?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制和神经系统功能恢复:中等质量证据显示,针对短期治疗(1-6 个月),IVIG 相较安慰剂可恢复神经系统功能、增加肌肉强度、改善残疾评分和神经传导检查。[111]Hughes RA, Donofrio P, Bril V, et al. Intravenous immune globulin (10% caprylate chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial. Lancet Neurol. 2008;7:136-144.http://www.ncbi.nlm.nih.gov/pubmed/18178525?tool=bestpractice.com[112]Eftimov F, Winer JB, Vermeulen M, et al. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy. Cochrane Database Syst Rev. 2013;(12):CD001797.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001797.pub3/abstracthttp://www.ncbi.nlm.nih.gov/pubmed/24379104?tool=bestpractice.com[113]Vermeulen M, van Doorn PA, Brand A, et al. Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy: a double blind, placebo controlled study. J Neurol Neurosurg Psychiatry. 1993;56:36-39.http://www.ncbi.nlm.nih.gov/pubmed/8429321?tool=bestpractice.com[114]Thompson N, Choudhary P, Hughes RA, et al. A novel trial design to study the effect of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol. 1996;243:280-285.http://www.ncbi.nlm.nih.gov/pubmed/8936360?tool=bestpractice.com[115]Hahn AF, Bolton CF, Zochodne D, et al. Intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a double-blind, placebo-controlled, cross-over study. Brain. 1996;119:1067-1077.http://brain.oxfordjournals.org/content/119/4/1067.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/8813271?tool=bestpractice.com[116]Mendell JR, Barohn RJ, Freimer ML, et al. Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy. Neurology. 2001;56:445-449.http://www.ncbi.nlm.nih.gov/pubmed/11222785?tool=bestpractice.com[117]van Schaik IN, Winer JB, de Haan R, et al. Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review. Lancet Neurol. 2002;1:491-498.http://www.ncbi.nlm.nih.gov/pubmed/12849334?tool=bestpractice.com
症状控制和神经系统功能恢复:中等质量证据显示,在改善神经系统功能方面,血浆置换可能比假置换疗效更佳。[119]Dyck PJ, Daube J, O'Brien P, et al. Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy. N Engl J Med. 1986;314:461-465.http://www.ncbi.nlm.nih.gov/pubmed/3511382?tool=bestpractice.com[120]Hahn AF, Bolton CF, Pillay N, et al. Plasma-exchange therapy in chronic inflammatory demyelinating polyneuropathy: a double-blind, sham-controlled, cross-over study. Brain. 1996;119:1055-1066.http://brain.oxfordjournals.org/content/119/4/1055.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/8813270?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制和神经系统功能恢复:中等质量证据显示,在改善神经系统功能方面,血浆置换可能比假置换疗效更佳。[119]Dyck PJ, Daube J, O'Brien P, et al. Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy. N Engl J Med. 1986;314:461-465.http://www.ncbi.nlm.nih.gov/pubmed/3511382?tool=bestpractice.com[120]Hahn AF, Bolton CF, Pillay N, et al. Plasma-exchange therapy in chronic inflammatory demyelinating polyneuropathy: a double-blind, sham-controlled, cross-over study. Brain. 1996;119:1055-1066.http://brain.oxfordjournals.org/content/119/4/1055.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/8813270?tool=bestpractice.com
症状控制和神经功能恢复:中等质量证据显示,在改善残疾评分方面,IVIG 和泼尼松龙一样有效。[43]Hughes R, Bensa S, Willison H, et al. Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 2001 Aug;50(2):195-201.http://www.ncbi.nlm.nih.gov/pubmed/11506402?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制和神经功能恢复:中等质量证据显示,在改善残疾评分方面,IVIG 和泼尼松龙一样有效。[43]Hughes R, Bensa S, Willison H, et al. Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 2001 Aug;50(2):195-201.http://www.ncbi.nlm.nih.gov/pubmed/11506402?tool=bestpractice.com
症状控制和神经系统功能恢复:低等质量证据显示,在改善神经系统功能的效果方面, 泼尼松龙可能比安慰剂疗效更佳。[118]Dyck PJ, O'Brien PC, Oviatt KF, et al. Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. Ann Neurol. 1982;11:136-141.http://www.ncbi.nlm.nih.gov/pubmed/7041788?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制和神经系统功能恢复:低等质量证据显示,在改善神经系统功能的效果方面, 泼尼松龙可能比安慰剂疗效更佳。[118]Dyck PJ, O'Brien PC, Oviatt KF, et al. Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. Ann Neurol. 1982;11:136-141.http://www.ncbi.nlm.nih.gov/pubmed/7041788?tool=bestpractice.com
症状控制和神经系统功能恢复:低等质量证据显示,在恢复神经系统功能、改善肌肉无力和神经传导检查方面,IVIG 可能和血浆置换一样有疗效。[123]Dyck PJ, Litchy WJ, Kratz KM, et al. A plasma exchange versus immune globulin infusion trial in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 1994;36:838-845.http://www.ncbi.nlm.nih.gov/pubmed/7998769?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制和神经系统功能恢复:低等质量证据显示,在恢复神经系统功能、改善肌肉无力和神经传导检查方面,IVIG 可能和血浆置换一样有疗效。[123]Dyck PJ, Litchy WJ, Kratz KM, et al. A plasma exchange versus immune globulin infusion trial in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 1994;36:838-845.http://www.ncbi.nlm.nih.gov/pubmed/7998769?tool=bestpractice.com