酸分泌下降可能影响某些药物的吸收（如左甲状腺素、地拉韦定、阿扎那韦、酮康唑、伊曲康唑、头孢泊肟、依诺沙星和双嘧达莫）。[45]Lahner E, Annibale B, Delle Fave G. Systemic review: Helicobacter pylori infection and impaired drug absorption. Aliment Pharmacol Ther. 2009;29:379-386.http://www.ncbi.nlm.nih.gov/pubmed/19053985?tool=bestpractice.com[46]Lahner E, Annibale B, Delle Fave G. Systemic review: impaired drug absorption related to the co-administration of antisecretory therapy. Aliment Pharmacol Ther. 2009;28:1219-1229.http://www.ncbi.nlm.nih.gov/pubmed/19302263?tool=bestpractice.com[47]Oosterhuis B, Jonkman JH, Andersson T, et al. Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose. Br J Clin Pharmac. 1991;32:569-572.http://www.ncbi.nlm.nih.gov/pubmed/1954072?tool=bestpractice.com[48]Soons PA, van den Berg G, Danhof M, et al. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects. Eur J Clin Pharmacol. 1992;42:319-324.http://www.ncbi.nlm.nih.gov/pubmed/1577051?tool=bestpractice.com[138]Checchi S, Montanaro A, Pasqui L, et al. L-thyroxine requirement in patients with autoimmune hypothyroidism and parietal cell antibodies. J Clin Endocrinol Metab. 2008;93:465-469.http://www.ncbi.nlm.nih.gov/pubmed/18042648?tool=bestpractice.com可能需要增加剂量以获得疗效。
