三苯双脒
经在中国进行研发和测试,三苯双脒是在过去 30 年内研制的唯一一种新驱虫药。该药物在作用机理方面与左旋咪唑和双羟萘酸噻嘧啶类似(烟碱乙酰胆碱受体激动剂),并具有与苯并咪唑类药物相似的治愈率。FDA 尚未批准将该药用于治疗蛔虫病,但显示有很好的应用前景。[53]Wu ZX, Fang YY, Liu YS. Effect of a novel drug - enteric coated tribendimidine in the treatment of intestinal nematode infection [in Chinese]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:23-26.http://www.ncbi.nlm.nih.gov/pubmed/16866136?tool=bestpractice.com[54]Hu Y, Xiao SH, Aroian RV. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009;3:e499.http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000499http://www.ncbi.nlm.nih.gov/pubmed/19668355?tool=bestpractice.com[55]Xiao SH, Hui-Ming W, Tanner M, et al. Tribendimidine: a promising, safe and broad-spectrum anthelminthic agent from China. Acta Trop. 2005;94:1-14.http://www.ncbi.nlm.nih.gov/pubmed/15777691?tool=bestpractice.com
硝唑尼特
一种 5-硝基噻唑衍生物,广谱的抗寄生虫药物,可能对于治疗蛔虫病有用。