血管内血量升高:有中等质量的证据证明,每天服用氟氢可的松 0.1 mg,会提高血管内血容量,改善自主神经衰竭的患者直立性低血压的症状。[14]Hickler RB, Thompson GR, Fox LM, et al. Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. N Engl J Med. 1959;261:788-791.http://www.ncbi.nlm.nih.gov/pubmed/14401690?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
血管内血量升高:有中等质量的证据证明,每天服用氟氢可的松 0.1 mg,会提高血管内血容量,改善自主神经衰竭的患者直立性低血压的症状。[14]Hickler RB, Thompson GR, Fox LM, et al. Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. N Engl J Med. 1959;261:788-791.http://www.ncbi.nlm.nih.gov/pubmed/14401690?tool=bestpractice.com
直立血压升高:有中等质量的证据证明,每天服用 2~3 次米多君,每次 10mg,可以有效升高直立血压,改善神经性直立性低血压患者症状。[16]Wright RA, Kaufmann HC, Perera R, et al. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998;51:120-124.http://www.ncbi.nlm.nih.gov/pubmed/9674789?tool=bestpractice.com[17]Low PA, Gilden JL, Freeman R, et al. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. JAMA. 1997;277:1046-1051. [Erratum in: JAMA. 1997;278:388.]http://www.ncbi.nlm.nih.gov/pubmed/9091692?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
直立血压升高:有中等质量的证据证明,每天服用 2~3 次米多君,每次 10mg,可以有效升高直立血压,改善神经性直立性低血压患者症状。[16]Wright RA, Kaufmann HC, Perera R, et al. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998;51:120-124.http://www.ncbi.nlm.nih.gov/pubmed/9674789?tool=bestpractice.com[17]Low PA, Gilden JL, Freeman R, et al. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. JAMA. 1997;277:1046-1051. [Erratum in: JAMA. 1997;278:388.]http://www.ncbi.nlm.nih.gov/pubmed/9091692?tool=bestpractice.com
血红蛋白水平的改善:有中等质量证据证明,重组红细胞生成素(25~50 U/kg 体重,每周皮下注射 3 次)可提高平均血红蛋白水平(从108 到 133 g/L),缓解自主神经衰竭患者中直立性低血压的症状。[25]Biaggioni I, Robertson D, Krantz S, et al. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med. 1994;121:181-186.http://www.ncbi.nlm.nih.gov/pubmed/8017744?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
血红蛋白水平的改善:有中等质量证据证明,重组红细胞生成素(25~50 U/kg 体重,每周皮下注射 3 次)可提高平均血红蛋白水平(从108 到 133 g/L),缓解自主神经衰竭患者中直立性低血压的症状。[25]Biaggioni I, Robertson D, Krantz S, et al. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med. 1994;121:181-186.http://www.ncbi.nlm.nih.gov/pubmed/8017744?tool=bestpractice.com