皮肤淋巴瘤年龄调整发病率是0.64/100,000[4]Criscione VD, Weinstock MA. Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002. Arch Dermatol. 2007;143:854-859.http://jamanetwork.com/journals/jamadermatology/fullarticle/414064http://www.ncbi.nlm.nih.gov/pubmed/17638728?tool=bestpractice.com然而，由于大多数是低级别恶性肿瘤，生存期长，总患病率更高。大约2/3的原发皮肤淋巴瘤是T细胞来源，大多数是蕈样霉菌病。MF在非霍奇金淋巴瘤中占不到3%。可能是因为诊断水平的提高和注册水平的完善，研究结果提示发病率逐渐升高。在美国，MF在老年、男性和黑人中更常见。[5]Weinstock MA, Horm JW. Mycosis fungoides in the United States. Increasing incidence and descriptive epidemiology. JAMA. 1988;260:42-46.http://www.ncbi.nlm.nih.gov/pubmed/3379722?tool=bestpractice.com与白人相比，黑人和亚裔患者年龄调整发病率分别是1.7和0.6。[6]Weinstock MA, Gardstein B. Twenty-year trends in the reported incidence of mycosis fungoides and associated mortality. Am J Public Health. 1999;89:1240-1244.http://ajph.aphapublications.org/doi/pdf/10.2105/AJPH.89.8.1240http://www.ncbi.nlm.nih.gov/pubmed/10432915?tool=bestpractice.com但是Sezary综合征在美国白人中的发病率更高。[7]Crandon S, Yancey MA. Sezary syndrome: a case study of cutaneous T-cell lymphoma. Clin J Oncol Nurs. 2009;13:157-159.http://www.ncbi.nlm.nih.gov/pubmed/19349262?tool=bestpractice.com在欧洲，芬兰癌症注册处报道CTCL的发病率在男性中高达2.5/100,000，女性中达1.5/100,000。[8]Väkevä L, Ranki A. Increased risk of secondary cancers in patient with primary cutaneous T cell lymphoma. J Invest Dermatol. 2000;115:62-65.http://www.jidonline.org/article/S0022-202X(15)40920-0/fulltexthttp://www.ncbi.nlm.nih.gov/pubmed/10886509?tool=bestpractice.com
