BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 五月 2019

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 主动肌和拮抗肌的同时收缩
  • 肌肉疼痛
  • 运动可诱发或加重是肌张力障碍普遍特征

其他诊断因素

  • 受累身体部位的扭转
  • 行为拮抗(感觉假象)
  • 受累身体部位的扭转
  • 行为拮抗(感觉假象)

危险因素

  • 肌张力障碍家族史
  • 受累部位的重复性运动
  • 出生创伤和儿童发育迟缓
  • 服用抗多巴胺类药物

诊断性检查

首要检查

  • 左旋多巴反应性
全部具体信息

需要考虑的检查

  • 头颅磁共振成像
  • 血清铜蓝蛋白水平
  • 24 小时尿铜
  • DYT1 基因检测
全部具体信息

治疗流程

贡献者

Associate Professor of Neurology

Parkinson's Disease and Movement Disorders Center

Beth Israel Deaconess Medical Center

Boston

MA

利益冲突披露
SF is employed by the Beth Israel Deaconess Medical Center, which has received funding from Allergan to support partial fellowship training.

Dr Samuel Frank would like to gratefully acknowledge Dr Ludy C. Shih, Dr David K. Simon, and Dr Daniel Tarsy, previous contributors to this topic.

利益冲突披露
LCS is now an employee of Biogen, Inc. and has received funding from the NIH Dystonia Coalition project for participant enrolment. DKS has received consulting fees from the Gerson Lehrman Group. DKS is an author of a reference cited in this topic. DT has received an unrestricted grant from Allergan and Medtronic being used for education. He received unrestricted funds for patient education from Allergan, Boehringer Ingelheim, Valeant, and Teva Neurosciences. He has received research funds from Solvay and Neurogen. DT is an author of a number of references cited in this topic.

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Reader in Clinical Neurology

Honorary Consultant

Institute of Neurology

National Hospital for Neurology and Neurosurgery

London

UK

利益冲突披露
PDL declares that she has no competing interests.

Assistant Professor

Director

Movement Disorder Center

Dept of Neurology

University of Florida

Tampa

FL

利益冲突披露
ZH has been a consultant for Allergan and a speaker for Novartis and TEVA.

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