1500 例活产儿中有 1 例发生房间隔缺损 (ASD)。继发孔型房间隔缺损占先天性心脏缺陷病例的 6%~10%,[1]Driscoll DJ. Fundamentals of pediatric cardiology. Philadelphia, PA: Lippincott Williams & Wilkins; 2006:73-8.[8]Feldt RH, Avasthey P, Yoshimasu F, et al. Incidence of congenital heart disease in children born to residents of Olmsted County, Minnesota, 1950-1969. Mayo Clin Proc. 1971 Dec;46(12):794-9.http://www.ncbi.nlm.nih.gov/pubmed/5128021?tool=bestpractice.com 且男女发病率之比为 1:2。[9]Weidman WH, Swan HJ, Dushane JW, et al. A hemodynamic study of atrial septal defect and associated anomalies involving the atrial septum. J Lab Clin Med. 1957 Aug;50(2):165-85.http://www.ncbi.nlm.nih.gov/pubmed/13449397?tool=bestpractice.com 继发孔型房间隔缺损占房间隔缺损病例的 75%。其他类型房间隔缺的发病率低得多:原发孔型 (15%)、静脉窦型 (5%) 和无顶冠状静脉窦 (1%)。此外,房间隔缺损的发生还与更严重的先天性心脏缺陷有关。