社交焦虑症状、总体焦虑、社会能力以及改善的治疗前后比较方法:有高质量的证据表明认知行为疗法(CBT)或选择性5-羟色胺再摄取抑制剂(SSRIs)在治疗社交恐惧症儿童时有效。[46]Segool NK, Carlson JS. Efficacy of cognitive-behavioral and pharmacologic treatments for children with social anxiety. Depress Anxiety. 2008;25(7):620-31.http://www.ncbi.nlm.nih.gov/pubmed/17999406?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
社交焦虑症状、总体焦虑、社会能力以及改善的治疗前后比较方法:有高质量的证据表明认知行为疗法(CBT)或选择性5-羟色胺再摄取抑制剂(SSRIs)在治疗社交恐惧症儿童时有效。[46]Segool NK, Carlson JS. Efficacy of cognitive-behavioral and pharmacologic treatments for children with social anxiety. Depress Anxiety. 2008;25(7):620-31.http://www.ncbi.nlm.nih.gov/pubmed/17999406?tool=bestpractice.com
改善评定量表的得分:有高质量的证据表明认知行为疗法(CBT)在治疗社交恐惧症中有效。[53]Ponniah K, Hollon SD. Empirically supported psychological interventions for social phobia in adults: a qualitative review of randomized controlled trials. Psychol Med. 2008 Jan;38(1):3-14.http://www.ncbi.nlm.nih.gov/pubmed/17640438?tool=bestpractice.com[54]Rowa K, Antony MM. Psychological treatments for social phobia. Can J Psychiatry. 2005 May;50(6):308-16.http://journals.sagepub.com/doi/pdf/10.1177/070674370505000603http://www.ncbi.nlm.nih.gov/pubmed/15999944?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善评定量表的得分:有高质量的证据表明认知行为疗法(CBT)在治疗社交恐惧症中有效。[53]Ponniah K, Hollon SD. Empirically supported psychological interventions for social phobia in adults: a qualitative review of randomized controlled trials. Psychol Med. 2008 Jan;38(1):3-14.http://www.ncbi.nlm.nih.gov/pubmed/17640438?tool=bestpractice.com[54]Rowa K, Antony MM. Psychological treatments for social phobia. Can J Psychiatry. 2005 May;50(6):308-16.http://journals.sagepub.com/doi/pdf/10.1177/070674370505000603http://www.ncbi.nlm.nih.gov/pubmed/15999944?tool=bestpractice.com
改善Liebowitz社交焦虑量表(LSAS)总分:有高质量证据表明苯乙肼、氯硝西泮和选择性5-羟色胺再摄取抑制剂治疗社交恐惧症有效。[65]Blanco C, Schneier FR, Schmidt A, et al. Pharmacological treatment of social anxiety disorder: a meta-analysis. Depress Anxiety. 2003;18(1):29-40.http://www.ncbi.nlm.nih.gov/pubmed/12900950?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善Liebowitz社交焦虑量表(LSAS)总分:有高质量证据表明苯乙肼、氯硝西泮和选择性5-羟色胺再摄取抑制剂治疗社交恐惧症有效。[65]Blanco C, Schneier FR, Schmidt A, et al. Pharmacological treatment of social anxiety disorder: a meta-analysis. Depress Anxiety. 2003;18(1):29-40.http://www.ncbi.nlm.nih.gov/pubmed/12900950?tool=bestpractice.com
改善总体临床印象量表(CGI)得分:有高质量的证据表明选择性5-羟色胺再摄取抑制剂和5-羟色胺-去甲肾上腺素再摄取抑制剂治疗社交恐惧症有效。[68]Ipser JC, Kariuki CM, Stein DJ. Pharmacotherapy for social anxiety disorder: a systematic review. Expert Rev Neurother. 2008 Feb;8(2):235-57.http://www.ncbi.nlm.nih.gov/pubmed/18271710?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善总体临床印象量表(CGI)得分:有高质量的证据表明选择性5-羟色胺再摄取抑制剂和5-羟色胺-去甲肾上腺素再摄取抑制剂治疗社交恐惧症有效。[68]Ipser JC, Kariuki CM, Stein DJ. Pharmacotherapy for social anxiety disorder: a systematic review. Expert Rev Neurother. 2008 Feb;8(2):235-57.http://www.ncbi.nlm.nih.gov/pubmed/18271710?tool=bestpractice.com
预防复发:有高质量的证据表明对超过12周帕罗西汀、依他普仑和舍曲林反应良好的社交恐惧症患者,在接下来的12周内会继续改善(也就是24周)。[73]Stein DJ, Versiani M, Hair T, et al. Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study. Arch Gen Psychiatry. 2002 Dec;59(12):1111-8.http://archpsyc.ama-assn.org/cgi/content/full/59/12/1111http://www.ncbi.nlm.nih.gov/pubmed/12470127?tool=bestpractice.com[74]Montgomery SA, Nil R, Durr-Pal N, et al. A 24-week randomized, double-blind, placebo-controlled study of escitalopram for the prevention of generalized social anxiety disorder. J Clin Psychiatry. 2005 Oct;66(10):1270-8.http://www.ncbi.nlm.nih.gov/pubmed/16259540?tool=bestpractice.com[75]Walker JR, van Ameringen MA, Swinson R, et al. Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20 weeks of sertraline treatment. J Clin Psychopharmacol. 2000 Dec;20(6):636-44.http://www.ncbi.nlm.nih.gov/pubmed/11106135?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
预防复发:有高质量的证据表明对超过12周帕罗西汀、依他普仑和舍曲林反应良好的社交恐惧症患者,在接下来的12周内会继续改善(也就是24周)。[73]Stein DJ, Versiani M, Hair T, et al. Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study. Arch Gen Psychiatry. 2002 Dec;59(12):1111-8.http://archpsyc.ama-assn.org/cgi/content/full/59/12/1111http://www.ncbi.nlm.nih.gov/pubmed/12470127?tool=bestpractice.com[74]Montgomery SA, Nil R, Durr-Pal N, et al. A 24-week randomized, double-blind, placebo-controlled study of escitalopram for the prevention of generalized social anxiety disorder. J Clin Psychiatry. 2005 Oct;66(10):1270-8.http://www.ncbi.nlm.nih.gov/pubmed/16259540?tool=bestpractice.com[75]Walker JR, van Ameringen MA, Swinson R, et al. Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20 weeks of sertraline treatment. J Clin Psychopharmacol. 2000 Dec;20(6):636-44.http://www.ncbi.nlm.nih.gov/pubmed/11106135?tool=bestpractice.com
改善 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量的证据表明,超过12周文拉法辛或帕罗西汀治疗社交恐惧症有效。[71]Liebowitz MB, Gelenberg AJ, Munjack D. Venlafaxine extended release vs placebo and paroxetine in social anxiety disorder. Arch Gen Psychiatry. 2005 Feb;62(2):190-8.http://archpsyc.ama-assn.org/cgi/content/full/62/2/190http://www.ncbi.nlm.nih.gov/pubmed/15699296?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量的证据表明,超过12周文拉法辛或帕罗西汀治疗社交恐惧症有效。[71]Liebowitz MB, Gelenberg AJ, Munjack D. Venlafaxine extended release vs placebo and paroxetine in social anxiety disorder. Arch Gen Psychiatry. 2005 Feb;62(2):190-8.http://archpsyc.ama-assn.org/cgi/content/full/62/2/190http://www.ncbi.nlm.nih.gov/pubmed/15699296?tool=bestpractice.com
改善评定量表得分:有中等质量证据表明,氯硝西泮在超过10周治疗社交恐惧症中有效且耐受性好。[78]Davidson JR, Potts N, Richichi E, et al. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol. 1993 Dec;13(6):423-8.http://www.ncbi.nlm.nih.gov/pubmed/8120156?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善评定量表得分:有中等质量证据表明,氯硝西泮在超过10周治疗社交恐惧症中有效且耐受性好。[78]Davidson JR, Potts N, Richichi E, et al. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol. 1993 Dec;13(6):423-8.http://www.ncbi.nlm.nih.gov/pubmed/8120156?tool=bestpractice.com
独立评级分析:有中等质量的证据表明苯乙肼较阿替洛尔或安慰剂在8周和16周治疗社交恐惧症中更有效。[27]Liebowitz, MR, Schneier F, Campeas R, et al. Phenelzine vs atenolol in social phobia. A placebo-controlled comparison. Arch Gen Psychiatry. 1992 Apr;49(4):290-300.http://www.ncbi.nlm.nih.gov/pubmed/1558463?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
独立评级分析:有中等质量的证据表明苯乙肼较阿替洛尔或安慰剂在8周和16周治疗社交恐惧症中更有效。[27]Liebowitz, MR, Schneier F, Campeas R, et al. Phenelzine vs atenolol in social phobia. A placebo-controlled comparison. Arch Gen Psychiatry. 1992 Apr;49(4):290-300.http://www.ncbi.nlm.nih.gov/pubmed/1558463?tool=bestpractice.com
改善社交恐惧症症状:有中等质量证据表明加巴喷丁超过14周治疗社交恐惧症有效。[89]Pande AC, Davidson JR, Jefferson JW, et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol. 1999 Aug;19(4):341-8.http://www.ncbi.nlm.nih.gov/pubmed/10440462?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善社交恐惧症症状:有中等质量证据表明加巴喷丁超过14周治疗社交恐惧症有效。[89]Pande AC, Davidson JR, Jefferson JW, et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol. 1999 Aug;19(4):341-8.http://www.ncbi.nlm.nih.gov/pubmed/10440462?tool=bestpractice.com
改善 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量证据表明,加巴喷丁在超过11周治疗社交恐惧症中有效。[90]Pande AC, Feltner DE, Jefferson JW, et al. Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol. 2004 Apr;24(2):141-9.http://www.ncbi.nlm.nih.gov/pubmed/15206660?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量证据表明,加巴喷丁在超过11周治疗社交恐惧症中有效。[90]Pande AC, Feltner DE, Jefferson JW, et al. Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol. 2004 Apr;24(2):141-9.http://www.ncbi.nlm.nih.gov/pubmed/15206660?tool=bestpractice.com
改善社交恐惧症清单量表分数和 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量证据表明,米氮平超过10周治疗社交恐惧症有效。[96]Muehlbacher M, Nickel MK, Nickel C, et al. Mirtazapine treatment of social phobia in women: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2005 Dec;25(6):580-3.http://www.ncbi.nlm.nih.gov/pubmed/16282842?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
改善社交恐惧症清单量表分数和 Liebowitz 社交焦虑量表(LSAS)总分:有中等质量证据表明,米氮平超过10周治疗社交恐惧症有效。[96]Muehlbacher M, Nickel MK, Nickel C, et al. Mirtazapine treatment of social phobia in women: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2005 Dec;25(6):580-3.http://www.ncbi.nlm.nih.gov/pubmed/16282842?tool=bestpractice.com