高钙血症可导致肾血管收缩,血容量减少和可逆性肾小球滤过率下降。 长期高钙血症和高尿钙可导致钙化,退行性变和肾小管萎缩/坏死。[3]Horwitz MJ, Hodak SP, Steward AF. Non-parathyroid hypercalcemia. In: Rosen CJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. Washington, DC: American Society of Bone and Mineral Research; 2013:562-71. 此外,静脉注射双膦酸盐治疗可合并急性肾损伤。[1]Stewart AF. Clinical practice. Hypercalcemia associated with cancer. N Engl J Med. 2005 Jan 27;352(4):373-9.http://www.ncbi.nlm.nih.gov/pubmed/15673803?tool=bestpractice.com[3]Horwitz MJ, Hodak SP, Steward AF. Non-parathyroid hypercalcemia. In: Rosen CJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. Washington, DC: American Society of Bone and Mineral Research; 2013:562-71.[7]Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol. 2001 Jan 15;19(2):558-67.http://www.ncbi.nlm.nih.gov/pubmed/11208851?tool=bestpractice.com
Acute kidney injury
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