肥胖与膝关节骨性关节炎的进展有很强关联,应鼓励肥胖患者减重。[17]Felson DT, Anderson JJ, Naimark A, et al. Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med. 1988;109:18-24.http://www.ncbi.nlm.nih.gov/pubmed/3377350?tool=bestpractice.com 没有其他治疗性干预措施可以预防或延缓骨关节炎的进展。此外,也没有药物可以预防骨性关节炎。有些证据显示多西环素可以延缓关节间隙变窄,尽管临床和实践意义有待进一步证实。[30]Brandt KD, Mazzuca SA, Katz BP, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015-2025.http://www.ncbi.nlm.nih.gov/pubmed/15986343?tool=bestpractice.com 氨基葡萄糖和硫酸软骨素对延缓骨关节炎的进展作用是有争议的,仍需进一步的研究与评价。[31]Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795-808.http://www.ncbi.nlm.nih.gov/pubmed/16495392?tool=bestpractice.com