皮质类固醇可降低死亡率，但增加脓毒症和脓毒性休克的神经肌肉无力
一个国际专家组回顾了近期的冲突证据，根据该专家组的意见，皮质类固醇可降低死亡率（约 2%），但会增加脓毒症和脓毒性休克患者神经肌肉无力的风险。该专家组的总结显示，总体的证据对于在伴或不伴休克的脓毒症患者中使用皮质类固醇提供了较弱的支持，但表示，不进行类固醇治疗的疗法也是合理的。患者的价值观和偏好可用于指导关于是否使用皮质类固醇的决策。对于优先考虑生存而非生活质量的患者，可能会选择接受皮质类固醇治疗，但是对于那些相对于避免死亡而言，更重视避免发生功能退化的患者来说，可能更倾向于选择不进行皮质类固醇治疗。
参见:治疗步骤小结
定义
病史和查体
诊断性检查
治疗流程
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作者 查看所有
Chief Executive
United Kingdom Sepsis Trust
Chief Executive
Global Sepsis Alliance
Programme Director
Survive Sepsis
Consultant in Critical Care and Anaesthesia
Heart of England NHS Foundation Trust
Birmingham
UK
利益冲突披露
RD has received payment for consultancy on sepsis from Kimal Plc, manufacturers of vascular access devices, from the Northumbria Partnership, a patient safety collaborative, and, where annual leave or other income was compromised in fulfilling his charity duties, from the UK Sepsis Trust. RD has received sponsorship to attend and speak at one meeting from Abbott Diagnostics. He is CEO of the UK Sepsis Trust and Global Sepsis Alliance, and advises HM Government, the World Health Organisation and NHS England on sepsis. Each of these positions demands that he express opinion on strategies around the recognition and management of sepsis.Consultant Acute Physician & Sepsis Lead
Department of Acute Medicine
Royal Hampshire County Hospital
Hampshire Hospitals NHS Foundation Trust
Winchester
UK
利益冲突披露
MIK is a national clinical advisor on sepsis to NHS England and a national clinical advisor on deterioration to NHS Improvement. He was reimbursed for a slide set by Relias Learning.Specialty Registrar in Gastroenterology and General Medicine
Maidstone and Tunbridge Wells NHS Trust
UK
利益冲突披露
AS is the clinical fellow to the National Medical Director at NHS Improvement. AS has been sponsored on two occasions by Dr Falk Pharma UK to attend specialist gastroenterology conferences abroad; there was no contractual obligation to disseminate product information.Consultant in Emergency Medicine
Clinical Academic
University of Plymouth
Lead Doctor
Devon Air Ambulance Trust
Derriford Hospital
Plymouth
UK
利益冲突披露
TN is a clinical adviser to the UK Sepsis Trust.Specialty Registrar in Emergency Medicine
Derriford Hospital
Plymouth
UK
利益冲突披露
EC declares that he has no competing interests.Dr Ron Daniels, Dr Matt Inada-Kimand, Dr Aamir Saifuddin, Dr Tim Nutbeam, and Dr Edward Berry would like to gratefully acknowledge Dr Lewys Richmond and Dr Paul Kempen, previous contributors to this topic. LR and PK declare that they have no competing interests.
同行评议专家 查看所有
Professor of Medicine
Infectious Disease Division
Rhode Island Hospital
Alpert Medical School of Brown University
Providence
RI
利益冲突披露
SMO declares that he has no competing interests.Associate Professor
NYU School of Medicine
Medical Director of Critical Care
Bellevue Hospital Center
New York
NY
利益冲突披露
LE serves as the guidelines co-chair and on the steering committee of the Surviving Sepsis Campaign.
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