早期非精原细胞瘤的化疗
短期博莱霉素、依托泊苷和顺铂 (BEP) 联合治疗可以作为 RPLND 的一个替代方案，并已显示出对早期非精原细胞瘤患者治疗的益处。[67]Albers P, Siener R, Krege S, et al; German Testicular Cancer Study Group. Randomized phase III trial comparing retroperitoneal lymph node dissection with one course of bleomycin and etoposide plus cisplatin chemotherapy in the adjuvant treatment of clinical stage I nonseminomatous testicular germ cell tumors: AUO trial AH 01/94 by the German Testicular Cancer Study Group. J Clin Oncol. 2008;26:2966-2972.http://jco.ascopubs.org/content/26/18/2966.fullhttp://www.ncbi.nlm.nih.gov/pubmed/18458040?tool=bestpractice.com无复发生存率的提高：高级别证据提示在接近5年的随访中，BEP与手术相比，能够提高无复发生存率（分别为99%和92%）。这个证据是在针对382例早期非精原细胞瘤的患者中进行的III期随机对照研究中得出的结论，这个研究评估了博来霉素、依托泊苷和顺铂（BEP）的化疗疗效与腹膜后淋巴结清扫术疗效的不同。[67]Albers P, Siener R, Krege S, et al; German Testicular Cancer Study Group. Randomized phase III trial comparing retroperitoneal lymph node dissection with one course of bleomycin and etoposide plus cisplatin chemotherapy in the adjuvant treatment of clinical stage I nonseminomatous testicular germ cell tumors: AUO trial AH 01/94 by the German Testicular Cancer Study Group. J Clin Oncol. 2008;26:2966-2972.http://jco.ascopubs.org/content/26/18/2966.fullhttp://www.ncbi.nlm.nih.gov/pubmed/18458040?tool=bestpractice.com系统评价或者受试者＞200名的随机对照临床试验（RCT）。相对于北美洲，这种治疗方法在欧洲进行得更好。[53]Cullen MH, Stenning SP, Parkinson MC, et al. Short-course adjuvant chemotherapy in high-risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report. J Clin Oncol. 1996;14:1106-1113.http://www.ncbi.nlm.nih.gov/pubmed/8648364?tool=bestpractice.com在北美，对于早期非精原细胞瘤睾丸癌患者使用BEP方案更多地被认为是一种新兴治疗方式。
