通过合适的治疗,绝大多数精原细胞瘤或非精原细胞瘤患者会被治愈。即使复发,通过化疗仍然有治愈的可能。如果出现转移,在低风险的患者中联合化疗可以有将近90%的反应率来根治肿瘤。[68]Horwich A, Sleijfer DT, Fosså SD, et al. Randomized trial of bleomycin, etoposide, and cisplatin compared with bleomycin, etoposide and carboplatin in good-prognosis metastatic nonseminomatous germ cell cancer. J Clin Oncol. 1997;15:1844-1852.http://www.ncbi.nlm.nih.gov/pubmed/9164194?tool=bestpractice.com即使对初始化疗反应不佳的患者——一组预后较差的人群中——20%-25%的患者可以达到长期缓解或有机会通过含异环磷酰胺在内的联合化疗进行治愈。[41]Association for Genitourinary Medicine (AGUM), Medical Society for the Study of Venereal Disease (MSSVD). 2002 National guidelines for the management of late syphilis. London: Association for Genitourinary Medicine (AGUM), Medical Society for the Study of Venereal Disease (MSSVD); 2002.
因为有对复发疾病的根治性疗法的存在,必须要进行严格的监测计划来对疾病复发进行早期监测。在化疗过程中,应该动态监测肿瘤标志物水平,因为肿瘤标志物对预后的提示起到一定作用。[69]Mazumdar M, Bajorin DF, Bacik J, et al. Predicting outcome to chemotherapy in patients with germ cell tumors: the value of the rate of decline of human chorionic gonadotrophin and alpha-fetoprotein during therapy. J Clin Oncol. 2001;19:2534-2541.http://www.ncbi.nlm.nih.gov/pubmed/11331333?tool=bestpractice.com