BMJ Best Practice
最后审核时间： 六月 2019
最近更新时间： 二月 2019

小结

定义

病史和查体

关键诊断因素

  • 呼吸短促和疲乏
  • 淋巴结肿大
  • 脾肿大
  • 肝肿大
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其他诊断因素

  • 存在的危险因素
  • B 症状
  • 复发性感染
  • 瘀斑
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危险因素

  • 60 岁以上
  • 男性
  • 白种人
  • CLL 家族史
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诊断性检查

首要检查

  • 白细胞分类计数
  • 血涂片
  • 血红蛋白
  • 血小板计数
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需要考虑的检查

  • 荧光原位杂交 (FISH)
  • 分子遗传学检测分析
  • 直接抗人球蛋白试验 (DAT)
  • 免疫球蛋白水平
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治疗流程

急性

无症状早期（Binet A 和 B；Rai 0-II）

晚期 (Binet C；Rai III-IV) 或症状性疾病

疾病持续状态

晚期复发

早期复发或难治性疾病

贡献者

作者 查看所有

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

利益冲突披露
VM declares that she received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014.

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

利益冲突披露
SP declares that he has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda.

Dr Vidhya Murthy and Dr Shankaranarayana Paneesha would like to gratefully acknowledge Dr Robert Chen, a previous contributor to this monograph. RC declares that he has no competing interests.

同行评议专家 查看所有

Consultant Haemato-oncologist

Section of Haemato-Oncology

The Institute of Cancer Research

Sutton

UK

利益冲突披露
DC declares that he has no competing interests.

Associate Professor

Department of Medicine

Case Western Reserve University

Case Comprehensive Cancer Center

Cleveland

OH

利益冲突披露
PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.

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