大约 10% 的病例出现相关症状:发热、寒战、盗汗、体重减轻和疲惫。[3]Cheson BD, Bennett JM, Rai KR, et al. Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. Am J Hematol. 1988 Nov;29(3):152-63.http://www.ncbi.nlm.nih.gov/pubmed/3189311?tool=bestpractice.com
分期基于体格检查和血细胞计数。[12]Hallek M. State-of-the-art treatment of chronic lymphocytic leukaemia. Hematology Am Soc Hematol Educ Program. 2009:440-9.http://asheducationbook.hematologylibrary.org/cgi/content/full/2009/1/440http://www.ncbi.nlm.nih.gov/pubmed/20008230?tool=bestpractice.com[13]Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood. 2008 Jun 15;111(12):5446-56.http://bloodjournal.hematologylibrary.org/cgi/content/full/111/12/5446http://www.ncbi.nlm.nih.gov/pubmed/18216293?tool=bestpractice.com[11]Eichhorst B, Robak T, Montserrat E, et al.; ESMO Guidelines Committee. Chronic lymphocytic leukemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):v78-v84.http://annonc.oxfordjournals.org/content/26/suppl_5/v78.full.pdf+htmlhttp://www.ncbi.nlm.nih.gov/pubmed/26314781?tool=bestpractice.com