BMJ Best Practice
最后审核时间: 十月 2018
最近更新时间: 一月 2018

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 雷诺现象
  • 手指凹陷或溃疡
  • 手足肿胀

其他诊断因素

  • 疲劳
  • 干咳
  • 运动耐量下降
  • 体重减轻

危险因素

  • 硬皮病家族史
  • 免疫失调(例如 ANA 阳性)
  • 暴露于环境物质和毒素(例如硅尘或溶剂)

诊断性检查

首要检查

  • 血清自身抗体
  • 全血细胞计数 (FBC)
  • 尿素和血清肌酐
  • 红细胞沉降率 (ESR)
全部具体信息

需要考虑的检查

  • 高分辨率胸部 CT 扫描
  • 上消化道内镜检查 ± 活组织检查
  • 血清肌酶
  • EMG /神经传导检查
全部具体信息

治疗流程

贡献者

Maureen D. Mayes MD, MPH

Professor of Medicine

Division of Rheumatology and Clinical Immunogenetics

University of Texas Health Science Center

Houston Medical School

Houston

TX

利益冲突披露
MDM has served as a consultant to Cytori and Boehringer-Ingelheim; she has participated in clinical treatment trials for Boehringer-Ingelheim, Roche-Genentech, Intermune, Bayer, Corbus, and Cytori. MDM is an author of a number of references cited in this monograph.

Dr Maureen D. Mayes would like to gratefully acknowledge Dr Rajpreet K. Arora-Singh, a previous contributor to this monograph. RKA declares that she has no competing interests.

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Associate Professor of Medicine

Department of Rheumatology

Medical College of Wisconsin

Milwaukee

WI

利益冲突披露
MEC has been reimbursed by: Actelion International (and is a member of its speakers bureau); Encysive Pharmaceuticals; and MediQuest Therapeutics. She is local principal investigator for the SCOT trial, sponsored by NIH.

Associate Professor

Division of Rheumatic and Autoimmune Diseases

Department of Medicine

University of Minnesota

Minneapolis

MN

利益冲突披露
JM declares that he has no competing interests.

Consultant Rheumatologist

Department of Rheumatology

Freeman Hospital

Newcastle Upon Tyne

UK

利益冲突披露
BG declares that she has no competing interests.

Reader in Rheumatology and Consultant Rheumatologist

Musculoskeletal Research Group

University of Manchester

Manchester

UK

利益冲突披露
ALH declares that she has no competing interests.

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