预期寿命显著缩短,死亡率类似于或高于阿尔茨海默病。[5]Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29:125-132.http://www.ncbi.nlm.nih.gov/pubmed/17975326?tool=bestpractice.com 治疗对其并无帮助,并且它通常为一种进行性疾病。 在几乎所有患者中,任何原因引起的痴呆都不可逆转。[22]Clarfield AM. The decreasing prevalence of reversible dementias: an updated meta-analysis. Arch Intern Med. 2003 Oct 13;163(18):2219-29.http://archinte.ama-assn.org/cgi/content/full/163/18/2219http://www.ncbi.nlm.nih.gov/pubmed/14557220?tool=bestpractice.com