靶向治疗
由于发现了多种被认为参与子痫前期病理生理机制的物质,未来使用靶向治疗的可能性正在变为现实。潜在的靶点包括:血管内皮生长因子(由腺病毒载体递送)、松弛素类似物、西地那非以及其他炎性制剂。[60]Conrad KP. G-protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention. Hum Reprod Update. 2016 Sep;22(5):647-64.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001498/http://www.ncbi.nlm.nih.gov/pubmed/27385360?tool=bestpractice.com[61]Paauw ND, Terstappen F, Ganzevoort W, et al. Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure. Hypertension. 2017 Nov;70(5):998-1006.http://www.ncbi.nlm.nih.gov/pubmed/28893896?tool=bestpractice.com[62]Sibley CP. Treating the dysfunctional placenta. J Endocrinol. 2017 Aug;234(2):R81-97.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516438/http://www.ncbi.nlm.nih.gov/pubmed/28483805?tool=bestpractice.com 然而,因为这些物质在疾病进程中的确切作用目前尚不清楚,而且这些方法并不是没有风险,目前也没有治疗可用。