总的来说,FS 预后比无并发症的类风湿关节炎的预后差。与 RA 患者相比,FS 患者因感染和恶性肿瘤而引起的发病率和死亡率增加。据估计,五年死亡率介于 25%~36%,且感染是主要的死亡原因。[2]Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore). 1990;69:69-80.http://www.ncbi.nlm.nih.gov/pubmed/1969604?tool=bestpractice.com[8]Balint GP, Balint PV. Felty's syndrome. Best Pract Res Clin Rheumatol. 2004;18:631-645.http://www.ncbi.nlm.nih.gov/pubmed/15454123?tool=bestpractice.com 另外,与所有 RA 患者一样,FS 患者患心血管疾病的风险也增加。
FS 患者的中性粒细胞减少程度因时而异,多达 40% 的患者未经特异性治疗,其中性粒细胞减少即可出现自发缓解。[3]Bowman SJ, Bhavnani M, Geddes GC, et al. Large granular lymphocyte expansions in patients with Felty's syndrome: analysis using anti-T cell receptor V beta-specific monoclonal antibodies. Clin Exp Immunol. 1995;101:18-24.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1553309&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/7621587?tool=bestpractice.com 然而,尽管中性粒细胞计数正常,这些患者感染风险仍然增加。[2]Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore). 1990;69:69-80.http://www.ncbi.nlm.nih.gov/pubmed/1969604?tool=bestpractice.com