治愈率:有高质量的证据表明,与醋酸滴耳剂相比,抗菌素加皮质类固醇滴耳剂可使弥漫性急性外耳道炎患者的 21 天治愈率有所提高。[17]van Balen FA, Smit WM, Zuithoff NP, et al. Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial. BMJ. 2003;327:1201-1205.http://www.bmj.com/cgi/content/full/327/7425/1201http://www.ncbi.nlm.nih.gov/pubmed/14630756?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
治愈率:有高质量的证据表明,与醋酸滴耳剂相比,抗菌素加皮质类固醇滴耳剂可使弥漫性急性外耳道炎患者的 21 天治愈率有所提高。[17]van Balen FA, Smit WM, Zuithoff NP, et al. Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial. BMJ. 2003;327:1201-1205.http://www.bmj.com/cgi/content/full/327/7425/1201http://www.ncbi.nlm.nih.gov/pubmed/14630756?tool=bestpractice.com
治愈率:高质量证据表明,就提高弥漫性外耳道炎患者的 10 天治愈率来说,氧氟沙星滴耳剂与氢化可的松-新霉素-多黏菌素 B 滴耳剂同样有效。[21]Jones RN, Milazzo J, Seidlin M. Ofloxacin otic solution for treatment of otitis externa in children and adults. Arch Otolaryngol Head Neck Surg. 1997;123:1193-1200.http://www.ncbi.nlm.nih.gov/pubmed/9366699?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
治愈率:高质量证据表明,就提高弥漫性外耳道炎患者的 10 天治愈率来说,氧氟沙星滴耳剂与氢化可的松-新霉素-多黏菌素 B 滴耳剂同样有效。[21]Jones RN, Milazzo J, Seidlin M. Ofloxacin otic solution for treatment of otitis externa in children and adults. Arch Otolaryngol Head Neck Surg. 1997;123:1193-1200.http://www.ncbi.nlm.nih.gov/pubmed/9366699?tool=bestpractice.com
治愈率:有中等质量的证据表明,就提高急性弥漫性外耳道炎患者的 4 周治愈率来说,多黏菌素-新霉素-氢化可的松滴耳剂与醋酸铝滴耳剂同样有效。[18]Lambert IJ. A comparison of the treatment of otitis externa with "Otosporin" and aluminium acetate: a report from a services practice in Cyprus. J R Coll Gen Pract. 1981;31:291-294.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971024/pdf/jroyalcgprac00101-0037.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/6273551?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
治愈率:有中等质量的证据表明,就提高急性弥漫性外耳道炎患者的 4 周治愈率来说,多黏菌素-新霉素-氢化可的松滴耳剂与醋酸铝滴耳剂同样有效。[18]Lambert IJ. A comparison of the treatment of otitis externa with "Otosporin" and aluminium acetate: a report from a services practice in Cyprus. J R Coll Gen Pract. 1981;31:291-294.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971024/pdf/jroyalcgprac00101-0037.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/6273551?tool=bestpractice.com
治愈率:有中等质量的证据表明,就提高 14-28 天内的治愈率来说,氧氟沙星滴耳剂与多黏菌素-新霉素-氢化可的松滴耳剂同样有效。[20]Pistorius B, Westberry K, Drehobl M, et al. Prospective, randomized, comparative trial of ciprofloxacin otic drops, with or without hydrocortisone, vs. polymyxin B-neomycin-hydrocortisone otic suspension in the treatment of acute diffuse otitis externa. Infect Dis Clin Pract. 1999;8:387-395.
系统评价或者受试者>200名的随机对照临床试验(RCT)。
治愈率:有中等质量的证据表明,就提高 14-28 天内的治愈率来说,氧氟沙星滴耳剂与多黏菌素-新霉素-氢化可的松滴耳剂同样有效。[20]Pistorius B, Westberry K, Drehobl M, et al. Prospective, randomized, comparative trial of ciprofloxacin otic drops, with or without hydrocortisone, vs. polymyxin B-neomycin-hydrocortisone otic suspension in the treatment of acute diffuse otitis externa. Infect Dis Clin Pract. 1999;8:387-395.
严重外耳道炎的风险:源自观察性研究(病例对照和队列研究)的低质量证据表明,糖尿病患者发生严重外耳道炎的风险较高。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
严重外耳道炎的风险:源自观察性研究(病例对照和队列研究)的低质量证据表明,糖尿病患者发生严重外耳道炎的风险较高。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com
严重外耳道炎的风险:源自观察性研究(病例对照和队列研究)的低质量证据表明,免疫受损患者发生严重外耳道炎的风险较高。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
严重外耳道炎的风险:源自观察性研究(病例对照和队列研究)的低质量证据表明,免疫受损患者发生严重外耳道炎的风险较高。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com