糖尿病患者,接受放疗或免疫受损的患者发生严重外耳道炎的风险较高,这可改变对这些患者的处理方式。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com[8]Osguthorpe JD, Nielsen DR. Otitis externa: review and clinical update. Am Fam Physician. 2006;74:1510-1516.http://www.aafp.org/afp/20061101/1510.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/17111889?tool=bestpractice.com严重外耳道炎的风险:源自观察性研究(病例对照和队列研究)的低质量证据表明,免疫受损患者发生严重外耳道炎的风险较高。[1]Rosenfeld RM, Schwartz SR, Cannon CR, et al. American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(suppl 1):S1-S24.http://oto.sagepub.com/content/150/1_suppl/S1.longhttp://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com低质量的观察性(队列)研究或者受试者<200名且方法学存在缺陷的随机对照临床试验(RCT)。