发作性睡病

发作性睡病几乎是一种终身疾病。几乎一半的发作性睡病患者日常生活备受白天过度嗜睡(EDS) 和/或猝倒困扰损害。[108]Roy A. Psychiatric aspects of narcolepsy. Br J Psychiatry. 1976 Jun;128:562-5.http://www.ncbi.nlm.nih.gov/pubmed/1276566?tool=bestpractice.com

虽然有少数发作性睡病患者通过非药物策略成功抵抗睡眠过度，但是大部分的患者仍需要药物治疗。尽管使用药物，日间表现也很少能正常化。[111]Mitler MM, Aldrich MS, Koob GF, et al. Narcolepsy and its treatment with stimulants. ASDA standards of practice. Sleep. 1994 Jun;17(4):352-71.http://www.ncbi.nlm.nih.gov/pubmed/7973321?tool=bestpractice.com[124]Boivin DB, Montplaisir J, Petit D, et al. Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol. 1993 Feb;16(1):46-53.http://www.ncbi.nlm.nih.gov/pubmed/8093681?tool=bestpractice.com[125]Miller MM, Hajdukovic R, Erman MK. Treatment of narcolepsy with methamphetamine. Sleep. 1993 Jun;16(4):306-17.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267865/http://www.ncbi.nlm.nih.gov/pubmed/8341891?tool=bestpractice.com大部分患者的症状保持稳定，除非患者出现药物耐受性。