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炎症性关节炎可导致软骨破坏和骨侵蚀，并产生继发性骨关节炎。约 50% 的反应性关节炎 (ReA) 患者均可能发展为慢性关节炎。[45]Carter JD, Valeriano J, Vasey FB. Doxycycline versus doxycycline and rifampin in undifferentiated spondyloarthropathy with special reference to chlamydia-induced arthritis. A prospective, randomized 9-month comparison. J Rheumatol. 2004;31:1973-1980.http://www.ncbi.nlm.nih.gov/pubmed/15468362?tool=bestpractice.com[84]Khan MA. Update on spondyloarthropathies. Ann Intern Med. 2002;136:896-907.http://www.ncbi.nlm.nih.gov/pubmed/12069564?tool=bestpractice.com[86]Colmegna I, Espinoza LR. Recent advances in reactive arthritis. Curr Rheumatol Rep. 2005;7:201-207.http://www.ncbi.nlm.nih.gov/pubmed/15918996?tool=bestpractice.com[87]Leirisalo-Repo M, Helenius P, Hannu T, et al. Long-term prognosis of reactive salmonella arthritis. Ann Rheum Dis. 1997;56:516-520.http://www.ncbi.nlm.nih.gov/pubmed/9370874?tool=bestpractice.com[88]Yli-Kerttula T, Tertti R, Toivanen A. Ten-year follow up study of patients from a Yersinia pseudotuberculosis III outbreak. Clin Exp Rheumatol. 1995;13:333-337.http://www.ncbi.nlm.nih.gov/pubmed/7554560?tool=bestpractice.com[89]Rihl M, Klos A, Kohler L, et al. Infection and musculoskeletal conditions: reactive arthritis. Best Pract Res Clin Rheumatol. 2006;20:1119-1137.http://www.ncbi.nlm.nih.gov/pubmed/17127200?tool=bestpractice.com 若患者发展为慢性 ReA（持续时间大于 6 个月），则可尝试使用免疫抑制剂以减缓或停止关节破坏。
骨关节炎
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