目前尚无成功治疗或预防后 TLS 预后的相关数据。引入拉布立酶后,需要透析的急性肾功能衰竭病例数已显著减少。[35]Patte C, Sakiroglu C, Ansoborlo S, et al. Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Francaise d'Oncologie Pédiatrique LMB89 protocol. Ann Oncol. 2002;13:789-795.http://annonc.oxfordjournals.org/cgi/content/full/13/5/789http://www.ncbi.nlm.nih.gov/pubmed/12075750?tool=bestpractice.com医生对 TLS 的病理生理学的理解及相关认知的增加导致更好的管理和结果。官方管理指南尚未制定,但相关工作正在进行中。[16]Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol. 2008;26:2767-2778.http://www.ncbi.nlm.nih.gov/pubmed/18509186?tool=bestpractice.com[23]Tosi P, Barosi G, Lazzaro C, et al. Consensus conference on the management of tumor lysis syndrome. Haematologica. 2008;93:1877-1885.http://www.haematologica.org/cgi/reprint/93/12/1877http://www.ncbi.nlm.nih.gov/pubmed/18838473?tool=bestpractice.com 如果出现并发症(例如心律失常、癫痫发作或急性肾功能衰竭),结果和住院持续时间可能会发生变化。这些并发症大多数都可在大型专业中心得到成功治疗。