男性和女性的坏疽发病率相同。I 型坏死性筋膜炎常见于糖尿病和周围血管病的患者。它是坏死性筋膜炎在人群中最常见的形式。[5]Cohen J, Powderly WG, Berkley SF, et al. Cohen and Powderly: infectious diseases. 2nd ed. Philadelphia, PA: Mosby Elsevier; 2004.II 型坏死性筋膜炎在美国的年发病率为每 100,000 人 5-10 例。约半数的链球菌坏死性筋膜炎发生在年轻人和既往健康的人中。[13]Kihiczak GG, Schwartz RA, Kapila R. Necrotizing fasciitis: a deadly infection. J Eur Acad Dermatol Venereol. 2006;20:365-369.http://www3.interscience.wiley.com/cgi-bin/fulltext/118623496/HTMLSTARThttp://www.ncbi.nlm.nih.gov/pubmed/16643131?tool=bestpractice.com
在美国,气性坏疽的发病率每年近 3000 例。能导致血液供应中断的严重穿透伤或挤压伤是常见的诱发因素。[14]Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59:e10-e52.http://cid.oxfordjournals.org/content/59/2/e10.fullhttp://www.ncbi.nlm.nih.gov/pubmed/24973422?tool=bestpractice.com自发气性坏疽由腐败梭菌引起,相比由另一种梭状芽孢杆菌引起的外伤性坏疽更常见。[15]Delbridge MS, Turton EP, Kester RC. Spontaneous fulminant gas gangrene. Emerg Med J. 2005;22:520-521.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1726828&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/15983095?tool=bestpractice.com在毒品滥用者中,产气荚膜梭状芽胞杆菌、污泥梭状芽胞杆菌和诺维氏梭状芽胞杆菌是最常见的。[5]Cohen J, Powderly WG, Berkley SF, et al. Cohen and Powderly: infectious diseases. 2nd ed. Philadelphia, PA: Mosby Elsevier; 2004.
动脉粥样硬化的患者中,尽管血管因素使得缺血性坏疽的发病率高达 30%,但因动脉栓塞导致的缺血性坏疽的年发病率从 0.3% 到 3.5% 不等。[16]Canale ST, Beatty JH, eds. Campbell's operative orthopaedics. 11th ed. Philadelphia, PA: Mosby Elsevier; 2007.抗磷脂抗体综合征患者的肢体末梢坏疽的比例可达 9%。[17]Hirschmann JV, Raugi GJ. Blue (or purple) toe syndrome. J Am Acad Dermatol. 2009;60:1-20.http://www.ncbi.nlm.nih.gov/pubmed/19103358?tool=bestpractice.com[18]Baker WF Jr., Bick RL. The clinical spectrum of antiphospholipid syndrome. Hematol Oncol Clin N Am. 2008;22:33-52.http://www.ncbi.nlm.nih.gov/pubmed/18207064?tool=bestpractice.com在受副肿瘤性肢端血管综合征影响的恶性肿瘤中,最常见的皮肤发现是急性坏疽,这占到 60% 的病例。大多数雷诺氏现象患者是年龄介于 20 岁和 40 岁之间的女性,病灶出现在寒冷的月份。[17]Hirschmann JV, Raugi GJ. Blue (or purple) toe syndrome. J Am Acad Dermatol. 2009;60:1-20.http://www.ncbi.nlm.nih.gov/pubmed/19103358?tool=bestpractice.com