小结
定义
意义未明的单克隆丙种球蛋白病 (monoclonal gammopathy of undetermined significance, MGUS) 是一种无症状疾病，与发生多发性骨髓瘤和相关浆细胞增生性恶性肿瘤的风险增加相关。诊断该病，必须满足下列标准：1) 血清或尿液中存在单克隆 (monoclonal, M) 蛋白（血清浓度＜30 g/L [3 g/dL] 或尿液浓度＜500 mg/24 小时）；2) 骨髓中浆细胞＜10%（只有在 M 蛋白＞15 g/L [1.5 g/dL]、存在针对非 IgG 型 MGUS 或游离轻链比例异常时，才需要骨髓检查）；
[Figure caption and citation for the preceding image starts]: 经苏木精-伊红染色的骨髓活检切面显示浆细胞轻度增加。由 Ola Landgren, MD, PhD 提供 [Citation ends].
[Figure caption and citation for the preceding image starts]: CD138 免疫组化染色突显出小群浆细胞。由 Ola Landgren, MD, PhD 提供 [Citation ends].3) 不伴有与浆细胞增殖过程相关的溶骨性病变、贫血、高钙血症、肾功能不全或淀粉样变。[1]
病史和查体
诊断性检查
治疗流程
贡献者
作者 查看所有
Professor of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
利益冲突披露
SK has served as a consultant for Janssen, Abbvie, Amgen, Merck, Celgene, Takeda, and Skyline.Professor Shaji Kumar would like to gratefully acknowledge Dr Ola Landgren, a previous contributor to this topic. OL is an author of several references cited in this monograph.
Consultant Haemato-Oncologist
Section of Haemato-Oncology
Brookes Lawley Institute of Cancer
Sutton
UK
利益冲突披露
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