BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 五月 2019

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 小伤口出血
  • 术后出血
  • 出血家族史

其他诊断因素

  • 消化道出血
  • 鼻出血
  • 输血
  • 关节积血

危险因素

  • 阳性家族史
  • 近亲通婚
  • 淋巴组织增殖性疾病
  • 主动脉狭窄

诊断性检查

首要检查

  • 凝血酶原时间 (PT)
  • 活化部分凝血活酶时间 (APTT)
  • 全血细胞计数 (FBC)
  • 血管性血友病因子抗原
全部具体信息

需要考虑的检查

  • 血管性血友病因子多聚体分析
  • 血小板聚集
  • 因子 VIII - 血管性血友病因子结合试验
  • 甲状腺功能检查 (TFT)
全部具体信息

新兴检查

  • 突变分析
  • PFA-100 和其他血小板功能分析仪
全部具体信息

治疗流程

贡献者

Professor of Haemostasis and Thrombosis

Imperial College Academic Health Sciences Centre

Hammersmith Hospital

London

UK

利益冲突披露
ML has received consultancy fees from Pfizer, Shire, Portola and Roche, speaker fees from Pfizer and Bayer, and travel support from Bayer and Shire. ML is an author of a number of references cited in this topic.

Prof Mike Laffan would like to gratefully acknowledge Dr Barbara A. Konkle, a previous contributor to this topic.

利益冲突披露
BAK declares that she has no competing interests.

同行评议专家 查看所有

Director

Hemophilia Center of Western Pennsylvania

Pittsburgh

PA

利益冲突披露
MR is an author of a reference cited in this topic.

Consultant Haematologist and Director

Oxford Haemophilia & Thrombosis Centre

Churchill Hospital

Oxford

UK

利益冲突披露
DK declares that he has received payments from CSL Behring for giving a lecture and attending an advisory board. He is an author of a number of references cited in this topic.

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