CVI大约影响7％的人群。[3]Cesarone MR, Belcaro G, Nicolaides AN, et al. 'Real' epidemiology of varicose veins and chronic venous diseases: the San Valentino Vascular Screening Project. Angiology. 2002;53:119-130.http://www.ncbi.nlm.nih.gov/pubmed/11952101?tool=bestpractice.com[4]Evans CJ, Fowkes FG, Ruckley CV, et al. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health. 1999;53:149-153.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1756838/pdf/v053p00149.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/10396491?tool=bestpractice.com据估计，最严重形式的CVI——静脉性腿部溃疡的患病率在0.2％-1％之间。[3]Cesarone MR, Belcaro G, Nicolaides AN, et al. 'Real' epidemiology of varicose veins and chronic venous diseases: the San Valentino Vascular Screening Project. Angiology. 2002;53:119-130.http://www.ncbi.nlm.nih.gov/pubmed/11952101?tool=bestpractice.com[5]Grey JE, Harding KG, Enoch S. Venous and arterial leg ulcers. BMJ. 2006;332:347-350.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1363917/http://www.ncbi.nlm.nih.gov/pubmed/16470058?tool=bestpractice.com[6]Gohel MS, Barwell JR, Taylor M, et al. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial. BMJ. 2007;335:83.http://www.bmj.com/content/335/7610/83.fullhttp://www.ncbi.nlm.nih.gov/pubmed/17545185?tool=bestpractice.com治疗后，10个伤口中有7个复发。仅在美国，2006年治疗静脉性腿部溃疡的总花费为30亿美元。[7]Bergan JJ, Schmid-Schonbein GW, Smith PD, et al. Chronic venous disease. N Engl J Med. 2006;355:488-498.http://www.ncbi.nlm.nih.gov/pubmed/16885552?tool=bestpractice.com
