6% 至 20% 的精神病患者会出现 PPD,最常见于精神分裂症。[1]Verghese C, De Leon J, Josiassen RC. Problems and progress in the diagnosis and treatment of polydipsia and hyponatremia. Schizophr Bull. 1996;22:455-464.http://schizophreniabulletin.oxfordjournals.org/cgi/reprint/22/3/455http://www.ncbi.nlm.nih.gov/pubmed/8873296?tool=bestpractice.com[2]de Leon J. Polydipsia: a study in a long-term psychiatric unit. Eur Arch Psychiatry Clin Neurosci. 2003;253:37-39.http://www.ncbi.nlm.nih.gov/pubmed/12664312?tool=bestpractice.com[3]Illowsky BP, Kirch DG. Polydipsia and hyponatremia in psychiatric patients. Am J Psychiatry. 1988;145:675-683.http://www.ncbi.nlm.nih.gov/pubmed/3285701?tool=bestpractice.com情感障碍、神经性厌食症和人格障碍也与 PPD 有关联。
其他与 PPD 有关联的因素包括精神分裂症的阳性症状、典型强迫行为、减压方法和抑制抗胆碱能药药物不良反应所带来的影响。然而,一项研究重复了 Kraepelin 提出的精神分裂症患者阴性症状和精神紊乱与烦渴和水中毒之间的初步关联。[19]Bralet MC, Ton T, Falissard B. Schizophrenic patients with polydipsia and water intoxication more often have a form of schizophrenia first described by Kraepelin. Psychiatry Res. 2007;152:267-271.http://www.ncbi.nlm.nih.gov/pubmed/17445907?tool=bestpractice.com