分裂情感性精神障碍患者的预后（依据总体不良结局以及诸如工作职能和认知障碍等参数来评估）似乎优于精神分裂症患者，但不及心境障碍患者。[4]Jäger M, Haack S, Becker T, et al. Schizoaffective disorder: an ongoing challenge for psychiatric nosology. Eur Psychiatry. 2011;26:159-165.http://www.ncbi.nlm.nih.gov/pubmed/20646917?tool=bestpractice.com[74]Harrow M, Grossman LS, Herbener ES, et al. Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms. Br J Psychiatry. 2000;177:421-426.http://bjp.rcpsych.org/content/177/5/421.longhttp://www.ncbi.nlm.nih.gov/pubmed/11059995?tool=bestpractice.com[75]Jager M, Bottlender R, Strauss A, et al. Fifteen-year follow-up of ICD-10 schizoaffective disorders compared with schizophrenia and affective disorders. Acta Psychiatr Scand. 2004;109:30-37.http://www.ncbi.nlm.nih.gov/pubmed/14674956?tool=bestpractice.com[76]Torniainen M, Suvisaari J, Partonen T, et al. Cognitive impairments in schizophrenia and schizoaffective disorder: relationship with clinical characteristics. J Nerv Ment Dis. 2012;200:316-322.http://www.ncbi.nlm.nih.gov/pubmed/22456585?tool=bestpractice.com
情感症状
分裂情感性精神障碍中的双相型，即存在躁狂或混合发作，相较抑郁型似乎有更好的预后。
其他预后因素
与精神分裂症类似，预后不良的预测因素包括：隐匿病程，既往功能低下史，精神分裂症家族史，以精神病症状和阴性症状为主，发作间歇期恢复差，心境不协调的精神病症状，以及缺乏明确的诱发因素。[74]Harrow M, Grossman LS, Herbener ES, et al. Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms. Br J Psychiatry. 2000;177:421-426.http://bjp.rcpsych.org/content/177/5/421.longhttp://www.ncbi.nlm.nih.gov/pubmed/11059995?tool=bestpractice.com
