BMJ Best Practice
最后审核时间: 六月 2019
最近更新时间: 三月 2019

小结

定义

病史和查体

关键诊断因素

  • 认知障碍
  • 失语症
  • 四肢和/或共济失调步态
  • 肌阵挛

其他诊断因素

  • 疼痛感觉症状
  • 运动障碍

危险因素

  • 遗传易感性
  • 被朊病毒污染的手术器械
  • 输入血液或血液制品(变异型克雅氏病)
  • 从 1980 年到 1996 年英国的牛肉消费情况

诊断性检查

首要检查

  • 脑部 MRI
  • 脑电图 (EEG)
全部具体信息

需要考虑的检查

  • 振动诱导转化 (QuIC)
  • CSF 生物标志物
  • 朊蛋白基因检测
  • 活检(脑部,扁桃体)
全部具体信息

治疗流程

疾病持续状态

贡献者

Associate Professor

Department of Medicine

Division of Neurology

Centre for Prions and Protein Folding Diseases

University of Alberta

Edmonton

Alberta

Canada

利益冲突披露
VS declares that she has no competing interests.

Dr Valerie Sim would like to gratefully acknowledge Dr Michael D. Geschwind, Dr Amy Kuo, and Dr R. Ronald Finley, the previous contributors to this monograph. MDG participates in the speakers' bureau for Pfizer, Forest, and Novartis; is consultant for MedaCorp, Gerson-Lehman Group, and Clinical Advisors Incorporated; and is an author of a number of references cited in this monograph. RRF participates in the speakers' bureau for Pfizer, Forest, and Novartis. AK declares that she has no competing interests.

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Infectious Disease Specialist

Alabama Infectious Diseases Center

Huntsville

AL

利益冲突披露
AH declares that he has no competing interests.

Associate Professor of Medicine

University of Southern California

Keck School of Medicine

Los Angeles

CA

利益冲突披露
RAL declares that he has no competing interests.

Chief and Professor of Medicine

Division of Infectious Diseases and International Health

University of Virginia Health System

Charlottesville

VA

利益冲突披露
WAP declares that he has no competing interests.

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