BMJ Best Practice

证据

  • How do antiepileptic drugs compare for people with focal epilepsy?
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  • What are the benefits and harms of lamotrigine add-on in adults or children with drug-resistant partial epilepsy?
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  • How does lacosamide add-on therapy compare with placebo in people with partial epilepsy?
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  • How does phenytoin compare with sodium valproate in people with partial onset or generalized onset tonic-clonic seizures?
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  • In people with drug-resistant partial seizures, how does vagus nerve stimulation using high stimulation compare with low stimulation at improving outcomes?
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  • What are the benefits and harms of lamotrigine add-on in adults or children with drug-resistant partial epilepsy?
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  • How does lacosamide add-on therapy compare with placebo in people with partial epilepsy?
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  • What are the benefits and harms of treatment for prevention of sudden unexpected death in epilepsy (SUDEP)?
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证据评分

    证据 B

    认知功能障碍:有适当的证据表明,妊娠期间使用丙戊酸与使用其他抗癫痫药相比,会增加暴露胎儿到 3 岁时发生显著认知障碍的风险。[108]

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