药物
现有很多用于治疗有症状子宫肌瘤的药物可使肿瘤体积缩小,可显著缓解肌瘤引起的相关症状。然而,由于严重的不良反应不推荐绝经前期女性长期应用。术前应用可有效减小肌瘤大小,缓解月经过多引起的贫血。[55]Viswanathan M, Hartmann K, McKoy N, et al. Management of uterine fibroids: an update of the evidence. AHRQ evidence report/technology assessment no. 154. Evid Rep Technol Assess (Full Rep). 2007;1-122.http://www.ncbi.nlm.nih.gov/books/NBK38746/http://www.ncbi.nlm.nih.gov/pubmed/18288885?tool=bestpractice.com症状缓解;中等质量证据表明与安慰剂或术前无治疗相比肌瘤术前应用戈那瑞林类似物超过3个月可改善术前盆腔症状。中等质量证据表明与单纯应用GnRHa相比戈那瑞林和手术联合治疗可能降低将来手术或药物治疗可能。受试者<200名的随机对照临床试验(RCT)、受试者>200名且方法学存在缺陷的随机对照临床试验(RCT)、方法学存在缺陷的系统评价或者高质量的观察性(队列)研究。
药物治疗结束,肌瘤可很快恢复至原来大小且症状再次出现(比如GnRH激动剂治疗者结束12周内)。[42]Wolfman DJ, Ascher SM. Magnetic resonance imaging of benign uterine pathology. Top Magn Reson Imaging. 2006;17:399-407.http://www.ncbi.nlm.nih.gov/pubmed/17417087?tool=bestpractice.com复发率:中等质量证据表明与安慰剂或无治疗相比术前使用戈那瑞林类似物肌瘤复发。受试者<200名的随机对照临床试验(RCT)、受试者>200名且方法学存在缺陷的随机对照临床试验(RCT)、方法学存在缺陷的系统评价或者高质量的观察性(队列)研究。药物疗法也可有效地用于围绝经期患者,以便过渡其自然发生的绝经期,并且在许多病例中伴随肌瘤相关症状的自发性改善。[46]Wallach EE, Vlahos NF. Uterine myomas: an overview of development, clinical features, and management. Obstet Gynecol. 2004;104:393-406.http://www.ncbi.nlm.nih.gov/pubmed/15292018?tool=bestpractice.com
手术
保留子宫的手术像肌瘤切除和子宫动脉栓塞可有效缓解肌瘤相关月经过多和子宫增大引起的相关症状。5项研究中285例因月经过多行肌瘤切除的患者,术后81%的患者术后出血减少或完全解决了出血问题。[14]Buttram VC, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36:433-445.http://www.ncbi.nlm.nih.gov/pubmed/7026295?tool=bestpractice.com
文献报道了引起宫腔变形的肌瘤可导致不孕和早产、胎盘早剥、臀位和剖宫产等。[8]American Congress of Obstetricians and Gynecologists. ACOG practice bulletin: surgical alternatives to hysterectomy in the management of leiomyomas. Int J Gynaecol Obstet. 2001;73:285-293.http://www.ncbi.nlm.nih.gov/pubmed/11424914?tool=bestpractice.com然而,肌瘤切除术后5年内症状复发率高达50%。[55]Viswanathan M, Hartmann K, McKoy N, et al. Management of uterine fibroids: an update of the evidence. AHRQ evidence report/technology assessment no. 154. Evid Rep Technol Assess (Full Rep). 2007;1-122.http://www.ncbi.nlm.nih.gov/books/NBK38746/http://www.ncbi.nlm.nih.gov/pubmed/18288885?tool=bestpractice.com关于肌瘤切除的7项研究提示,术后流产率从41%降至19%。[70]Bajekal N, Li TC. Fibroids, infertility and pregnancy wastage. Hum Reprod Update. 2000;6:614-620.http://www.ncbi.nlm.nih.gov/pubmed/11129696?tool=bestpractice.com一项关于开腹肌瘤切除的回顾性研究得到了类似的结论,这些肌瘤未影响宫腔或未使宫腔变形。术后除了早孕流产率下降,中孕期流产率从17%降至0。[84]Li TC, Mortimer R, Cook ID. Myomectomy: a retrospective study to examine reproductive performance before and after surgery. Human Repro. 1999;14:1735-1740.http://www.ncbi.nlm.nih.gov/pubmed/10402378?tool=bestpractice.com
另一项研究比较了子宫肌瘤切除和子宫动脉栓塞后的临床结局,子宫动脉栓塞(UAE)术后3-5年因症状复发需进一步治疗的发生率为28%。[47]Broder MS, Goodwin S, Chen G, et al. Comparison of long-term outcomes of myomectomy and uterine artery embolization. Obstet Gynecol. 2002;100:864-868.http://www.ncbi.nlm.nih.gov/pubmed/12423842?tool=bestpractice.com
子宫切除由于能有效永久缓解肌瘤相关症状,故成为不保留子宫肌瘤患者最成功的治疗方式。然而,应告知患者术后12%的患者出现新的症状。[55]Viswanathan M, Hartmann K, McKoy N, et al. Management of uterine fibroids: an update of the evidence. AHRQ evidence report/technology assessment no. 154. Evid Rep Technol Assess (Full Rep). 2007;1-122.http://www.ncbi.nlm.nih.gov/books/NBK38746/http://www.ncbi.nlm.nih.gov/pubmed/18288885?tool=bestpractice.com