幼年特发性关节炎

利纳西普

一种已被证明对活动性全身型 JIA 有效的白介素-1 抑制剂。[102]Ilowite NT, Prather K, Lokhnygina Y, et al. Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis. Arthritis Rheumatol. 2014;66:2570-2579.http://onlinelibrary.wiley.com/doi/10.1002/art.38699/fullhttp://www.ncbi.nlm.nih.gov/pubmed/24839206?tool=bestpractice.com

利妥昔单抗

利妥昔单抗是一种 B 细胞靶向抗 CD20 抗体，该药输注已经成功地用于治疗成年人类风湿关节炎。[103]Edwards JC, Szczepanski L, Szechinski J, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004;350:2572-2581.http://www.nejm.org/doi/full/10.1056/NEJMoa032534#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/15201414?tool=bestpractice.com 此药还被用于治疗儿童和成人 SLE。迄今尚无在 JIA 患儿中开展且已发表的相关试验。然而，据报道，该药能有效控制成人的难治性 RF 阴性多关节疾病。[88]Cohen S, Hurd E, Cush J, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002;46:614-624.http://www.ncbi.nlm.nih.gov/pubmed/11920396?tool=bestpractice.com

戈利木单抗

戈利木单抗 (golimumab) 是抗肿瘤坏死因子 (TNF)-α 的重组人单克隆抗体。[104]Brunner HI, Ruperto N, Tzaribachev N, et al. Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial. Ann Rheum Dis. 2017 May 15 [Epub ahead of print].http://ard.bmj.com/content/early/2017/05/15/annrheumdis-2016-210456.longhttp://www.ncbi.nlm.nih.gov/pubmed/28507219?tool=bestpractice.com 在欧洲，它适用于与甲氨蝶呤联用治疗儿童多关节型幼年特发性关节炎。