BMJ Best Practice
最后审核时间： 十月 2018
最近更新时间： 一月 2018

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 关节痛
  • 无力
  • 血管炎
全部具体信息

其他诊断因素

  • 外周神经病变
  • Sicca 症状
  • 高血压
  • 雷诺氏现象
全部具体信息

危险因素

  • 丙型肝炎病毒 (HCV) 感染
  • 其他病毒感染
  • 自身免疫病
  • 淋巴组织增殖性疾病
全部具体信息

诊断性检查

首要检查

  • 空腹血清冷球蛋白定性分析
  • FBC
  • 全套的血液化学指标
  • ESR、CRP
全部具体信息

需要考虑的检查

  • HIV 抗体
  • ANA、SSA、ENA
  • 皮肤活检
全部具体信息

治疗流程

急性

混合型冷球蛋白血症

恶性肿瘤相关的冷球蛋白血症（l 型）

贡献者

Professor of Medicine

Chief, Division of Rheumatology and Clinical Immunology

Medical Director, Musculoskeletal Ultrasound Program

Program Director, Rheumatology Fellowship

University of Florida College of Medicine - Jacksonville

Jacksonville

FL

利益冲突披露
GSK declares that he has no competing interests.

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Rheumatologist

Road Clinic

Lakewood

WA

利益冲突披露
DT has received a fee from an educational grant from the Center of Excellence for organizing CME South Sound Bond Club conference.

Associate Professor

University of Turin

Chief

Myeloma Unit

Ospedale Molinette

Turin

Italy

利益冲突披露
AP declares that he has no competing interests.

Instructor in Hematology

Department of Hematology

Hopital Huriez CHRU

Lille

France

利益冲突披露
XL has received lecture fees and research funding from Janssen-Cilag, Celgene, Chugai, Amgen, Novartis, Mundipharma, and Roche. XL is an author of a number of references cited in this monograph.

Consultant Physician and Rheumatologist

Centre for Rheumatic Diseases

Glasgow Royal Infirmary

Glasgow

UK

利益冲突披露
RM declares that he has no competing interests.

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