莫西沙星
这种抗生素似乎可以有效治疗吸入性肺炎和原发性肺脓肿。一项研究发现,其疗效和安全性与氨苄西林/舒巴坦相似,30.5 天的中位治疗时间后,临床应答率为 66.7%。[62]Polenakovik H, Burdette SD, Polenakovik S. Moxifloxacin is efficacious for treatment of community-acquired lung abscesses in adults. Clin Infect Dis. 2005;41:764-765.https://academic.oup.com/cid/article/41/5/764/332312/Moxifloxacin-Is-Efficacious-for-Treatment-ofhttp://www.ncbi.nlm.nih.gov/pubmed/16080108?tool=bestpractice.com[63]Ott SR, Allewelt M, Lorenz J, et al. Moxifloxacin vs ampicillin/sulbactam in aspiration pneumonia and primary lung abscess. Infection. 2008;36:23-30.http://www.ncbi.nlm.nih.gov/pubmed/18231720?tool=bestpractice.com
多尼培南
这是一种较新的碳青霉烯类药物,抗菌谱类似于亚胺培南/西司他丁和美罗培南。似乎有高抗厌氧菌活性。虽然预计其对混合菌群有效,已发表的临床经验有限。[64]Snydman DR, Jacobus NV, McDermott LA. In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group. Antimicrob Agents Chemother. 2008;52:4492-4496.http://aac.asm.org/content/52/12/4492.fullhttp://www.ncbi.nlm.nih.gov/pubmed/18838581?tool=bestpractice.com