避免吸烟和致癌物职业暴露(例如芳香胺、亚硝胺和丙烯醛)以及避免接触化学物质(例如砷)污染的水,并在可能的情况下,限制盆腔放疗。[41]Messing EM, Madeb R, Young T, et al. Long-term outcome of hematuria home screening for bladder cancer in men. Cancer. 2006;107:2173-2179.http://onlinelibrary.wiley.com/doi/10.1002/cncr.22224/fullhttp://www.ncbi.nlm.nih.gov/pubmed/17029275?tool=bestpractice.com
及时治疗和防治尿路感染、移除尿路结石和避免长时间留置导尿管会减少炎症(膀胱癌的一个病因),最大程度地减少环磷酰胺化疗和放疗的暴露也将有助于减少医源性膀胱癌。[42]Cookson MS, Herr HW, Zhang ZF, et al. The treated natural history of high risk superficial bladder cancer: 15-year outcome. J Urol. 1997;158:62-67.
据报道,二甲双胍可能会增强化疗和放疗的抗肿瘤疗效,可显著降低膀胱癌的发病率。[43]Tseng CH. Metformin may reduce bladder cancer risk in Taiwanese patients with type 2 diabetes mellitus. Acta Diabetol. 2014;51:295-303.http://www.ncbi.nlm.nih.gov/pubmed/24509842?tool=bestpractice.com