案例#1
一名 40 岁的巴西男性移民,于伦敦居住 22 年,检查其血清发现克氏锥虫感染为阳性。此结果是在对献血者常规筛查过程中,由 ELISA 检测出并被放射免疫沉淀测定 (RIPA) 所确定的。患者已有 14 年的献血史,但现在已经不能再参加献血。患者否认有心脏或胃肠道症状,并在体格检查中未出现特殊病征。
案例#2
一名 50 岁澳大利亚人,从 1985 年至今居住并工作于阿根廷(查科省)农村区域。患者在假期返回澳大利亚探亲期间,因心悸和晕厥症状被收入急症科。他否认有消化道症状。体格检查发现低血压、心脏扩大和全身性水肿症状。
其他表现
AIDS 患者、器官移植的患者和服用高剂量免疫抑制剂的患者,可出现克氏锥虫脑膜脑炎和/或心肌炎。[21]Ferreira MS. Chagas disease and immunosuppression. Mem Inst Oswaldo Cruz. 1999;94(suppl 1):325-327.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000700062&lng=en&nrm=isohttp://www.ncbi.nlm.nih.gov/pubmed/10677748?tool=bestpractice.com也可出现皮肤症状。[15]Sartori AM, Sotto MN, Braz LM, et al. Reactivation of Chagas disease manifested by skin lesions in a patient with AIDS. Trans R Soc Trop Med Hyg. 1999;93:631-632.http://www.ncbi.nlm.nih.gov/pubmed/10717752?tool=bestpractice.com这类患者的死亡率较高,尤其是在诊断延误的情况下。对于 AIDS 患者,可出现疾病复发现象(与其他机会性感染相似),特别是在患者 CD4 计数<2 x 10^9/L(<200 细胞/mm^3)的情况下。[8]Almeida EA, Ramos AN Jr, Correia D, et al. Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010). Rev Soc Bras Med Trop. 2011;44:762-770.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600021&lng=en&nrm=iso&tlng=enhttp://www.ncbi.nlm.nih.gov/pubmed/22231251?tool=bestpractice.com[18]Ferreira MS, Borges AS. Some aspects of protozoan infections in immunocompromised patients - a review. Mem Inst Oswaldo Cruz. 2002;97:443-457.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000400001&lng=en&nrm=iso&tlng=enhttp://www.ncbi.nlm.nih.gov/pubmed/12118272?tool=bestpractice.com在这些病例中,75% 至 80% 可出现单病灶或多病灶的急性脑膜脑炎,且出现心脏损害的病例约为 45%。在巴西,恰加斯病复发于 2004 年,被加入确定 HIV 阳性患者的 AIDS 状态的机会性疾病列表中。[8]Almeida EA, Ramos AN Jr, Correia D, et al. Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010). Rev Soc Bras Med Trop. 2011;44:762-770.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600021&lng=en&nrm=iso&tlng=enhttp://www.ncbi.nlm.nih.gov/pubmed/22231251?tool=bestpractice.com[22]Ramos AN Jr. Inclusion of Chagas' disease reactivation as a condition for AIDS case definition to epidemiological surveillance in Brazil [in Portuguese]. Rev Soc Bras Med Trop. 2004;37:192-193.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000200018&lng=en&nrm=iso&tlng=enhttp://www.ncbi.nlm.nih.gov/pubmed/15094911?tool=bestpractice.com[23]Sartori AM, Neto JE, Nunes EV, et al. Trypanosoma cruzi parasitemia in chronic Chagas disease: comparison between human immunodeficiency virus (HIV)-positive and HIV-negative patients. J Infect Dis. 2002;186:872-875.http://jid.oxfordjournals.org/content/186/6/872.fullhttp://www.ncbi.nlm.nih.gov/pubmed/12198628?tool=bestpractice.com
急性口腔传播恰加斯病的暴发可表现为非典型的体征和症状,包括皮疹、胃肠道出血、黄疸、AST/ALT 升高和重度心脏衰竭。[11]Shikanai-Yasuda MA, Carvalho NB. Oral transmission of Chagas disease. Clin Infect Dis. 2012;54:845-852.http://cid.oxfordjournals.org/content/54/6/845.fullhttp://www.ncbi.nlm.nih.gov/pubmed/22238161?tool=bestpractice.com[24]Yoshida N. Molecular mechanisms of Trypanosoma cruzi infection by oral route. Mem Inst Oswaldo Cruz. 2009;104(suppl 1):101-107.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900015&lng=en&nrm=iso&tlng=enhttp://www.ncbi.nlm.nih.gov/pubmed/19753464?tool=bestpractice.com[25]Pereira KS, Schmidt FL, Guaraldo AM, et al. Chagas' disease as a foodborne illness. J Food Prot. 2009;72:441-446.http://www.ncbi.nlm.nih.gov/pubmed/19350996?tool=bestpractice.com[26]Nóbrega AA, Garcia MH, Tatto E, et al. Oral transmission of Chagas disease by consumption of açaí palm fruit, Brazil. Emerg Infect Dis. 2009;15:653-655.http://wwwnc.cdc.gov/eid/article/15/4/08-1450_article.htmhttp://www.ncbi.nlm.nih.gov/pubmed/19331764?tool=bestpractice.com[27]Pinto AY, Ferreira AG Jr, Valente Vda C, et al. Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole. Rev Panam Salud Publica. 2009;25:77-83.http://www.ncbi.nlm.nih.gov/pubmed/19341528?tool=bestpractice.com[28]Pan American Health Organization. Guía para vigilancia, prevención, controle y manejo clínico da doença de Chagas aguda transmitida por alimentos [in Portuguese]. Rio de Janeiro, Brazil: PANAFTOSA-VP/OPAS/OMS: PAHO/HSD/CD/539.09; 2009:92.http://bvs.panalimentos.org/local/File/Guia_Doenca_Chagas_2009.pdf[29]Alarcón de Noya B, Díaz-Bello Z, Colmenares C, et al. Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela. J Infect Dis. 2010;201:1308-1315.http://jid.oxfordjournals.org/content/201/9/1308.fullhttp://www.ncbi.nlm.nih.gov/pubmed/20307205?tool=bestpractice.com与其他传播形式引起的急性病例相比,这些患者的发病率和死亡率较高。[11]Shikanai-Yasuda MA, Carvalho NB. Oral transmission of Chagas disease. Clin Infect Dis. 2012;54:845-852.http://cid.oxfordjournals.org/content/54/6/845.fullhttp://www.ncbi.nlm.nih.gov/pubmed/22238161?tool=bestpractice.com
胃扩张和巨输尿管症可见于患有恰加斯病的 HIV 阴性患者。然而,这些临床表现较为少见。[30]Dias JC, Coura JR. Clinica e terapeutica da doença de Chagas. Rio de Janeiro, Brazil: FIOCRUZ; 1997:486.