苄硝唑对非确定症状和早期恰加斯心脏病患者治疗的效果:有大量证据显示,服用苄硝唑 60 天可使血清转换在第 36 个月呈阴性。[223]de Andrade AL, Zicker F, de Oliveira RM, et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet. 1996;348:1407-1413.http://www.ncbi.nlm.nih.gov/pubmed/8937280?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
苄硝唑对非确定症状和早期恰加斯心脏病患者治疗的效果:有大量证据显示,服用苄硝唑 60 天可使血清转换在第 36 个月呈阴性。[223]de Andrade AL, Zicker F, de Oliveira RM, et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet. 1996;348:1407-1413.http://www.ncbi.nlm.nih.gov/pubmed/8937280?tool=bestpractice.com
苄硝唑对非确定症状和非重度的慢性恰加斯病患者治疗的效果:有大量证据显示此项治疗可预防或减慢心脏病的发展,同时可显著减少致死风险。[225]Viotti R, Vigliano C, Lococo B, et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006;144:724-734.http://www.ncbi.nlm.nih.gov/pubmed/16702588?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
苄硝唑对非确定症状和非重度的慢性恰加斯病患者治疗的效果:有大量证据显示此项治疗可预防或减慢心脏病的发展,同时可显著减少致死风险。[225]Viotti R, Vigliano C, Lococo B, et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006;144:724-734.http://www.ncbi.nlm.nih.gov/pubmed/16702588?tool=bestpractice.com
对比苄硝唑和硝呋莫司:有少量证据显示,与用硝呋莫司治疗相比,用苄硝唑治疗的患者有较好的动物接种诊断结果。[227]Coura JR, de Abreu LL, Willcox HP, et al. Comparative controlled study on the use of benznidazole, nifurtimox and placebo, in the chronic form of Chagas' disease, in a field area with interrupted transmission. I. Preliminary evaluation [in Portuguese]. Rev Soc Bras Med Trop. 1997;30:139-144.http://www.ncbi.nlm.nih.gov/pubmed/9148337?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
对比苄硝唑和硝呋莫司:有少量证据显示,与用硝呋莫司治疗相比,用苄硝唑治疗的患者有较好的动物接种诊断结果。[227]Coura JR, de Abreu LL, Willcox HP, et al. Comparative controlled study on the use of benznidazole, nifurtimox and placebo, in the chronic form of Chagas' disease, in a field area with interrupted transmission. I. Preliminary evaluation [in Portuguese]. Rev Soc Bras Med Trop. 1997;30:139-144.http://www.ncbi.nlm.nih.gov/pubmed/9148337?tool=bestpractice.com
苄硝唑对非确定症状患者治疗的效果:有少量证据显示,服用苄硝唑 60 天使血清转换在第 48 个月呈阴性、动物接种诊断在第48个月呈阳性,且在治疗结束后可治愈60%感染 3 到 4 年的患者。[226]Sosa Estani S, Segura EL, Ruiz AM, et al. Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease. Am J Trop Med Hyg. 1998;59:526-529.http://www.ajtmh.org/content/59/4/526.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/9790423?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
苄硝唑对非确定症状患者治疗的效果:有少量证据显示,服用苄硝唑 60 天使血清转换在第 48 个月呈阴性、动物接种诊断在第48个月呈阳性,且在治疗结束后可治愈60%感染 3 到 4 年的患者。[226]Sosa Estani S, Segura EL, Ruiz AM, et al. Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease. Am J Trop Med Hyg. 1998;59:526-529.http://www.ajtmh.org/content/59/4/526.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/9790423?tool=bestpractice.com