BMJ Best Practice
最后审核时间： 十月 2018
最近更新时间： 六月 2018

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 运动迟缓
  • 静止性震颤
  • 强直
全部具体信息

其他诊断因素

  • 面具脸
  • 发音过弱
  • 运动减少性构音障碍
  • 写字过小症
全部具体信息

危险因素

  • 年龄增长
  • 青年发病的家族性帕金森病史
  • 编码葡萄糖脑苷脂酶的基因发生突变
  • 接触 1-甲基-4-苯基-1,2,3,6-四氢吡啶 (MPTP)
全部具体信息

诊断性检查

首要检查

  • 多巴胺能药物试验
全部具体信息

需要考虑的检查

  • 脑部 MRI 扫描
  • 功能性神经成像（多巴胺转运蛋白成像，例如 FP-CIT 或 beta-CIT SPECT，或是氟多巴 PET）
  • 嗅觉测试
  • 基因检测
全部具体信息

新兴检查

  • 基底节超声检查
  • 使用碘-123 间碘苄胍 (meta-iodobenzylguanidine, MIBG) 进行心交感神经检查
全部具体信息

治疗流程

疾病持续状态

轻度帕金森症

中度帕金森症

晚期帕金森症

贡献者

作者 查看所有

Assistant Professor

Department of Neurology

Division of Movement Disorders

Northwestern University Feinberg School of Medicine

Chicago

IL

利益冲突披露
DB serves on the speaker's bureau for Teva Pharmaceuticals, and ACADIA Pharmaceutical, Inc. He has received consultancy fees from US WorldMeds and grant support from the Parkinson Foundation. He is on the board of directors for Rock Steady Boxing Windy City.

Dr Danny Bega would like to gratefully acknowledge Dr Meredith Spindler, Dr Jayne R. Wilkinson, and Dr Andrew D. Siderowf, the previous contributors to this monograph. MS, JRW, and ADS declare that they have no competing interests.

同行评议专家 查看所有

Assistant Clinical Professor

Department of Neurology

UCSF Medical Center

Parkinson's Disease Research

Education and Clinical Center

San Francisco

CA

利益冲突披露
GAG declares that he has no competing interests.

Assistant Professor of Neurology

Jefferson Medical College

Thomas Jefferson University

Philadelphia

PA

利益冲突披露
DK declares that he has no competing interests.

Consultant Neurologist / Honorary Senior Lecturer

Institute of Neurological Sciences

Southern General Hospital / University of Glasgow

Glasgow

UK

利益冲突披露
DG is an author of a reference cited in this monograph.

Reader in Clinical Neurology

Honorary Consultant

Institute of Neurology

National Hospital for Neurology and Neurosurgery

London

UK

利益冲突披露
PDL declares that she has no competing interests.

Assistant Professor

Department of Neurology

University of Florida College of Medicine

Gainesville

FL

利益冲突披露
NM declares that he has no competing interests.

使用此内容应接受我们的免责声明。