BMJ Best Practice
最后审核时间： 十月 2018
最近更新时间： 一月 2018

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 血栓的特征
全部具体信息

其他诊断因素

  • 出血的特征
  • 无症状性
  • 头痛
  • 全身无力/疲乏
全部具体信息

危险因素

  • 受影响的家庭成员
  • 年龄＞40 岁
  • Budd-Chiari 综合征
全部具体信息

诊断性检查

首要检查

  • 血红蛋白
  • 血细胞比容
  • 白细胞计数
  • 血小板计数
全部具体信息

需要考虑的检查

  • 血氧饱和度
  • 血清促红细胞生成素
  • RBC 总量
  • 检测除 JAK2 之外的基因组异常
全部具体信息

治疗流程

急性

非妊娠成人：血栓风险较低/中等，无显著的血小板增多

非妊娠成人：血栓风险高，无显著的血小板增多

非妊娠成人：显著血小板增多

孕妇

儿童

疾病持续状态

非妊娠患者：不耐受其他治疗药物（包括羟基脲、芦可替尼和干扰素）、高龄或者寿命较短

贡献者

作者 查看所有

Assistant Professor

Leukemia Department

Division of Cancer Medicine

The University of Texas MD Anderson Cancer Center

Houston

TX

利益冲突披露
PB has received research support from Incyte and honorarium for a single advisory board participation.

Professor

Department of Leukemia

Division of Cancer Medicine

The University of Texas MD Anderson Cancer Center

Houston

TX

利益冲突披露
SV has received research support from Incyte Corporation, Astrazeneca, Lilly Oncology, Roche, Geron, NS Pharma, Bristol Myers Squibb, Celgene, Gilead, Seattle Genetics, Promedior, CTI BioPharma Corp., Galena BioPharma, Pfizer, Genentech, and Blueprint Pharmaceuticals.

Dr Prithviraj Bose and Dr Srdan Verstovsek would like to gratefully acknowledge Dr Constantine Tam, Dr Scott J. Samuelson, and Dr Josef T. Prchal, previous contributors to this monograph. CT, SJS, and JTP declare that they have no competing interests.

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Associate Professor of Medicine

Innsbruck Medical University

Innsbruck

Austria

利益冲突披露
CP declares that he has no competing interests.

Assistant Member

Human Oncology and Pathogenesis Program Leukemia Service

Department of Medicine

Memorial Sloan Kettering Cancer Center

New York

NY

利益冲突披露
None declared.

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